Literature summary for 4.4.1.21 extracted from

Lebeer, S.; Claes, I.J.; Verhoeven, T.L.; Shen, C.; Lambrichts, I.; Ceuppens, J.L.; Vanderleyden, J.; De Keersmaecker, S.C.
Impact of luxS and suppressor mutations on the gastrointestinal transit of Lactobacillus rhamnosus GG (2008), Appl. Environ. Microbiol., 74, 4711-4718.

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Protein Variants

Protein Variants	Comment	Organism
additional information	the luxS knockout mutant CMPG5412 shows drastically reduced persistence in mice which is related to less survival in simulated gastric juice, indicating that LuxS metabolism is crucial for the gastric stress resistance, the suppressor mutations in the luxS knockout mutant CMPG5413 compensates for the metabolic defects of the luxS mutation and restores the resistance to gastric juice but causes a defect in adherence, biofilm formation, and exopolysaccharide production	Lacticaseibacillus rhamnosus

Organism

Organism	UniProt	Comment	Textmining
Lacticaseibacillus rhamnosus	-	-	-
Lacticaseibacillus rhamnosus GG	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-ribosylhomocysteine	-	Lacticaseibacillus rhamnosus	L-homocysteine + 4,5-dihydroxy-2,3-pentanedione	-	?
S-ribosylhomocysteine	-	Lacticaseibacillus rhamnosus GG	L-homocysteine + 4,5-dihydroxy-2,3-pentanedione	-	?

Synonyms

Synonyms	Comment	Organism
LuxS	-	Lacticaseibacillus rhamnosus

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Release 2023.1 (January 2023)