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Literature summary for 4.4.1.20 extracted from

  • Freiberg, J.J.; Dahl, M.; Tybjaerg-Hansen, A.; Grande, P.; Nordestgaard, B.G.
    Leukotriene C4 synthase and ischemic cardiovascular disease and obstructive pulmonary disease in 13,000 individuals (2009), J. Mol. Cell. Cardiol., 46, 579-586.
    View publication on PubMed

Application

Application Comment Organism
medicine (-1072)GNA and (-444)ANC promoter polymorphisms of LTC4 synthase influence risk of transient ischemic attack and ischemic stroke, but not risk of ischemic heart disease/coronary atherosclerosis, asthma, or chronic obstructive pulmonary disease in a Danish population. The (-1072)A allele has a frequency of 0.07 while the (-444)C allele has a frequency of 0.29. The (-1072)A and (-444)C alleles are on different haplotypes, thus one polymorphism cannot tag the other. Genetically altered leukotriene C4 synthase activity may play a role in thrombi formation rather than the development of atherosclerosis Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens Q16873
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Synonyms

Synonyms Comment Organism
leukotriene C4 synthase
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Homo sapiens