Literature summary for 4.4.1.14 extracted from

Capitani, G.; Hohenester, E.; Feng, L.; Storici, P.; Kirsch, J.F.; Jansonius, J.N.
Structure of 1-aminocyclopropane-1-carboxylate synthase, a key enzyme in the biosynthesis of the plant hormone ethylene (1999), J. Mol. Biol., 294, 745-756.

Search for more literature for 4.4.1.14

Cloned(Commentary)

Cloned (Comment)	Organism
-	Malus domestica

Crystallization (Commentary)

Crystallization (Comment)	Organism
crystal structure at 2.4 A resolution	Malus domestica

Protein Variants

Protein Variants	Comment	Organism
K273A	no ACC synthase activity	Malus domestica
Y233F	24fold increase in Km	Malus domestica
Y85A	no ACC synthase activity	Malus domestica
Y85F	partially active ACC synthase	Malus domestica
Y85W	partially active ACC synthase	Malus domestica

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
52000	-	2 * 52000, SDS-PAGE	Malus domestica

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
S-adenosyl-L-methionine	Malus domestica	-	1-aminocyclopropane-1-carboxylate + methylthioadenosine	-	?

Organism

Organism	UniProt	Comment	Textmining
Malus domestica	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
recombinant ACC synthase	Malus domestica

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
S-adenosyl-L-methionine	-	Malus domestica	1-aminocyclopropane-1-carboxylate + methylthioadenosine	-	?

Subunits

Subunits	Comment	Organism
dimer	2 * 52000, SDS-PAGE	Malus domestica

Synonyms

Synonyms	Comment	Organism
ACC synthase	-	Malus domestica

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	-	Malus domestica

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Release 2023.1 (January 2023)