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Literature summary for 4.4.1.14 extracted from
- Structure, catalytic activity and evolutionary relationships of 1-aminocyclopropane-1-carboxylate synthase, the key enzyme of ethylene synthesis in higher plants (2002), Acta Biochim. Pol., 49, 757-774.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli and Saccharomyces cerevisiae | Cucurbita pepo |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| in complex with pyridoxal 5'-phosphate and aminoethoxyvinylglycine | Solanum lycopersicum |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| R286A | almost complete loss of activity | Solanum lycopersicum |
| R286I | almost complete loss of activity | Solanum lycopersicum |
| R286L | low affinity for pyridoxal 5' phosphate and S-adenosylmethionine | Solanum lycopersicum |
| R286T | almost complete loss of activity | Solanum lycopersicum |
| R286V | almost complete loss of activity | Solanum lycopersicum |
| R407L | 20fold increase in Km for s-adenosyl-l-methionine | Malus domestica |
| Y233F | 24fold increase in Km for s-adenosyl-L-methionine | Malus domestica |
| Y85A | inactive ACC synthase | Malus domestica |
| Y92F | partially active ACC synthase | Solanum lycopersicum |
| Y92H | no activity | Solanum lycopersicum |
| Y92L | no activity | Solanum lycopersicum |
| Y92W | partially active ACC synthase | Solanum lycopersicum |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| aminoethoxyvinylglycine | - |
Solanum lycopersicum |  |
| L-vinylglyine | - |
Solanum lycopersicum | |
| methoxyethoxyvinylglycine | - |
Solanum lycopersicum | |
| rhizobitoxine | - |
Solanum lycopersicum | |
| S-(3-deazaadenosyl)homocysteine | - |
Solanum lycopersicum | |
| S-adenosyl-L-homocysteine | - |
Solanum lycopersicum | |
| S-adenosyl-L-methionine | mechanism-based inactivation | Solanum lycopersicum | |
| S-isobutyl-1-deazaadenosine | - |
Solanum lycopersicum | |
| S-isobutyl-3-deazaadenosine | - |
Solanum lycopersicum | |
| S-isobutyl-7-deazaadenosine | - |
Solanum lycopersicum | |
| S-isobutyladenosine | - |
Solanum lycopersicum | |
| sinefungin | naturally occuring antifungal antibiotic isolated from Streptomyces griseus | Solanum lycopersicum | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytoplasm | - |
Solanum lycopersicum | 5737 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 50200 | - |
x * 50200, isoenzyme ACS2 | Solanum tuberosum |
| 51000 | - |
x * 51000, isoenzymes ACS4 and ACS5 | Lupinus albus |
| 52900 | - |
x * 52900, iosenzymes ACS1A and ACS1B | Solanum tuberosum |
| 53100 | - |
x * 53100, iosenzyme ACS1 | Oryza sativa |
| 53300 | - |
x * 53300, iosenzyme ACS2 | Citrus sinensis |
| 53800 | - |
x * 53800, iosenzymes ACS4 and ACS5 | Arabidopsis thaliana |
| 54100 | - |
x * 54100, iosenzyme ACS1 | Citrus sinensis |
| 54100 | - |
x * 54100, iosenzyme ACS1 | Pelargonium x hortorum |
| 54600 | - |
x * 54600, iosenzyme ACS1 | Arabidopsis thaliana |
| 54600 | - |
x * 54600, iosenzyme ACS1 | Vigna radiata |
| 55000 | - |
x * 55000, iosenzyme ACS2 | Brassica oleracea |
| 55000 | - |
x * 55000, iosenzymes ACS1 and ACS3 | Lupinus albus |
| 55600 | - |
x * 55600, iosenzyme ACS2 | Arabidopsis thaliana |
| 55800 | - |
x * 55800, iosenzyme ACS | Cucurbita maxima |
| 55800 | - |
x * 55800, iosenzyme ACS1A | Cucurbita pepo |
| 55900 | - |
x * 55900, iosenzyme ACS1B | Cucurbita pepo |
| 56000 | - |
x * 56000, iosenzyme ACS1 | Cucumis melo |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine | Solanum tuberosum | - |
1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| S-adenosyl-L-methionine | Arabidopsis thaliana | - |
1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| S-adenosyl-L-methionine | Lupinus albus | - |
1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| S-adenosyl-L-methionine | Vigna radiata | - |
1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| S-adenosyl-L-methionine | Solanum lycopersicum | - |
1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| S-adenosyl-L-methionine | Brassica oleracea | - |
1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| S-adenosyl-L-methionine | Cucurbita pepo | - |
1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| S-adenosyl-L-methionine | Oryza sativa | - |
1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| S-adenosyl-L-methionine | Cucurbita maxima | - |
1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| S-adenosyl-L-methionine | Citrus sinensis | - |
1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| S-adenosyl-L-methionine | Cucumis melo | - |
1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| S-adenosyl-L-methionine | Malus domestica | - |
1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| S-adenosyl-L-methionine | Pelargonium x hortorum | - |
1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Arabidopsis thaliana | - |
- |
- |
| Brassica oleracea | - |
- |
- |
| Citrus sinensis | - |
- |
- |
| Cucumis melo | - |
- |
- |
| Cucurbita maxima | - |
- |
- |
| Cucurbita pepo | - |
- |
- |
| Lupinus albus | - |
- |
- |
| Malus domestica | - |
apple | - |
| Oryza sativa | - |
- |
- |
| Pelargonium x hortorum | - |
- |
- |
| Solanum lycopersicum | - |
- |
- |
| Solanum tuberosum | - |
- |
- |
| Vigna radiata | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine | - |
Solanum tuberosum | 1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| S-adenosyl-L-methionine | - |
Arabidopsis thaliana | 1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| S-adenosyl-L-methionine | - |
Lupinus albus | 1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| S-adenosyl-L-methionine | - |
Vigna radiata | 1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| S-adenosyl-L-methionine | - |
Solanum lycopersicum | 1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| S-adenosyl-L-methionine | - |
Brassica oleracea | 1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| S-adenosyl-L-methionine | - |
Cucurbita pepo | 1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| S-adenosyl-L-methionine | - |
Oryza sativa | 1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| S-adenosyl-L-methionine | - |
Cucurbita maxima | 1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| S-adenosyl-L-methionine | - |
Citrus sinensis | 1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| S-adenosyl-L-methionine | - |
Cucumis melo | 1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| S-adenosyl-L-methionine | - |
Malus domestica | 1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
| S-adenosyl-L-methionine | - |
Pelargonium x hortorum | 1-aminocyclopropane-1-carboxylate + methylthioadenosine | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| ? | x * 50200, isoenzyme ACS2 | Solanum tuberosum |
| ? | x * 51000, isoenzymes ACS4 and ACS5 | Lupinus albus |
| ? | x * 52900, iosenzymes ACS1A and ACS1B | Solanum tuberosum |
| ? | x * 53100, iosenzyme ACS1 | Oryza sativa |
| ? | x * 53100-54800 | Solanum lycopersicum |
| ? | x * 53300, iosenzyme ACS2 | Citrus sinensis |
| ? | x * 53800, iosenzymes ACS4 and ACS5 | Arabidopsis thaliana |
| ? | x * 54100, iosenzyme ACS1 | Citrus sinensis |
| ? | x * 54100, iosenzyme ACS1 | Pelargonium x hortorum |
| ? | x * 54600, iosenzyme ACS1 | Arabidopsis thaliana |
| ? | x * 54600, iosenzyme ACS1 | Vigna radiata |
| ? | x * 55000, iosenzyme ACS2 | Brassica oleracea |
| ? | x * 55000, iosenzymes ACS1 and ACS3 | Lupinus albus |
| ? | x * 55600, iosenzyme ACS2 | Arabidopsis thaliana |
| ? | x * 55800, iosenzyme ACS | Cucurbita maxima |
| ? | x * 55800, iosenzyme ACS1A | Cucurbita pepo |
| ? | x * 55900, iosenzyme ACS1B | Cucurbita pepo |
| ? | x * 56000, iosenzyme ACS1 | Cucumis melo |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| ACC synthase | - |
Solanum lycopersicum |
| ACC synthase | - |
Malus domestica |
| ACS | - |
Solanum tuberosum |
| ACS | - |
Arabidopsis thaliana |
| ACS | - |
Lupinus albus |
| ACS | - |
Vigna radiata |
| ACS | - |
Solanum lycopersicum |
| ACS | - |
Brassica oleracea |
| ACS | - |
Cucurbita pepo |
| ACS | - |
Oryza sativa |
| ACS | - |
Cucurbita maxima |
| ACS | - |
Citrus sinensis |
| ACS | - |
Cucumis melo |
| ACS | - |
Malus domestica |
| ACS | - |
Pelargonium x hortorum |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Solanum tuberosum | |
| pyridoxal 5'-phosphate | - |
Arabidopsis thaliana | |
| pyridoxal 5'-phosphate | - |
Lupinus albus | |
| pyridoxal 5'-phosphate | - |
Vigna radiata | |
| pyridoxal 5'-phosphate | - |
Solanum lycopersicum | |
| pyridoxal 5'-phosphate | - |
Brassica oleracea | |
| pyridoxal 5'-phosphate | - |
Cucurbita pepo | |
| pyridoxal 5'-phosphate | - |
Oryza sativa | |
| pyridoxal 5'-phosphate | - |
Cucurbita maxima | |
| pyridoxal 5'-phosphate | - |
Citrus sinensis | |
| pyridoxal 5'-phosphate | - |
Cucumis melo | |
| pyridoxal 5'-phosphate | - |
Malus domestica | |
| pyridoxal 5'-phosphate | - |
Pelargonium x hortorum | |
pI Value
| Organism | Comment | pI Value Maximum | pI Value |
|---|---|---|---|
| Cucurbita maxima | isoenzyme ACS | - |
5 |
| Solanum tuberosum | isoenzyme ACS2 | - |
5.74 |
| Brassica oleracea | isoenzyme ACS2 | - |
5.9 |
| Vigna radiata | isoenzyme ACS1 | - |
6 |
| Pelargonium x hortorum | isoenzyme ACS1 | - |
6.4 |
| Cucumis melo | isoenzyme ACS1 | - |
6.41 |
| Lupinus albus | isoenzyme ACS5 | - |
6.44 |
| Lupinus albus | isoenzyme ACS4 | - |
6.58 |
| Citrus sinensis | isoenzyme ACS1 | - |
6.63 |
| Citrus sinensis | isoenzyme ACS2 | - |
6.72 |
| Lupinus albus | isoenzyme ACS1 | - |
7.06 |
| Arabidopsis thaliana | isoenzymes ACS1 and ACS2 | 7.4 | 7.3 |
| Arabidopsis thaliana | isoenzyme ACS5 | - |
7.5 |
| Lupinus albus | isoenzyme ACS3 | - |
7.61 |
| Solanum tuberosum | isoenzyme ACS1A | - |
7.86 |
| Oryza sativa | isoenzyme ACS1 | - |
8.2 |
| Arabidopsis thaliana | isoenzyme ACS4 | - |
8.2 |
| Solanum tuberosum | isoenzyme ACS1B | - |
8.23 |
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