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Literature summary for 4.4.1.13 extracted from

  • Cooper, A.J.; Pinto, J.T.
    Cysteine S-conjugate beta-lyases (2006), Amino Acids, 30, 1-15.
    View publication on PubMed
Search for more literature for 4.4.1.13

Application

Application Comment Organism
medicine possible beneficial or useful consequences of cysteine S-conjugate beta-lyase activity include targeting of prodrugs. They can unmask suitably designed prodrugs in target tumors/tissues. Other favorable beta-lyase reactions are associated with activation of S-cysteine conjugates derived from allium foods into reactive persulfide or sulfane sulfur progenitors. Allium-derived S-allylcysteinyl constituents are effective inhibitors of the cancer process. Thus the study of the biochemistry of allium-derived cysteine S-conjugates may lead to new avenues for cancer treatment Rattus norvegicus

Localization

Localization Comment Organism GeneOntology No. Textmining
cytosol
-
 Rattus norvegicus 5829
-

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
RS-CH2-CH(NH3+)COO- + H2O Rattus norvegicus
-
 RSH + NH3 + pyruvate
-
 ir

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
kidney
-
 Rattus norvegicus
-
liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
 approximately between 0.6 and 6.4 with S-(1,2-dichlorovinyl)-L-cysteine or S-(1,1,2,2-tetrafluoroethyl)-L-cysteine as substrate Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
RS-CH2-CH(NH3+)COO- + H2O
-
 Rattus norvegicus RSH + NH3 + pyruvate
-
 ir
S-(1,1,2,2-tetrafluoroethyl)-L-cysteine + H2O
-
 Rattus norvegicus NH3 + pyruvate + 1,1,2,2-tetrafluoroethanethiol
-
 ir
S-(1,2-dichlorovinyl)-L-cysteine + H2O
-
 Rattus norvegicus NH3 + pyruvate + 1,2-dichloroethylenethiol
-
 ir
S-allyl-L-cysteine + H2O
-
 Rattus norvegicus NH3 + pyruvate + prop-2-ene-1-thiol
-
 ir
S-allylmercapto-L-cysteine + H2O
-
 Rattus norvegicus NH3 + pyruvate + allyl hydrodisulfide
-
 ir
S-methylmercapto-L-cysteine + H2O
-
 Rattus norvegicus NH3 + pyruvate + methanethiol
-
 ir
S-penta-1,3-dienylmercapto-L-cysteine + H2O
-
 Rattus norvegicus NH3 + pyruvate + penta-1,3-dien-1-yl hydrodisulfide
-
 ir
S-propylmercapto-L-cysteine + H2O
-
 Rattus norvegicus NH3 + pyruvate + propyl hydrodisulfide
-
 ir
Te-phenyl-L-tellurocysteine + H2O
-
 Rattus norvegicus NH3 + pyruvate + phenyltelluride
-
 ir

Synonyms

Synonyms Comment Organism
cysteine S-conjugate beta-lyase
-
 Rattus norvegicus
glutamine transaminase K
-
 Rattus norvegicus
GTK
-
 Rattus norvegicus

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Rattus norvegicus