Literature summary for 4.4.1.13 extracted from

Gentry-Weeks, C.R.; Spokes, J.; Thompson, J.
beta-Cystathionase from Bordetella avium. Role(s) of lysine 214 and cysteine residues in activity and cytotoxicity (1995), J. Biol. Chem., 270, 7695-7702.

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Protein Variants

Protein Variants	Comment	Organism
C117G	inactive protein, pyridoxal 5'-phosphate is not detectable in the mutant protein, enhanced susceptibility to chymotrypsin digestion	Bordetella avium
C279	activity is comparable with that of the native enzyme	Bordetella avium
C309A	inactive protein, pyridoxal 5'-phosphate is not detectable in the mutant protein, enhanced susceptibility to chymotrypsin digestion	Bordetella avium
C88A	activity is comparable with that of the native enzyme	Bordetella avium

Inhibitors

Inhibitors	Comment	Organism	Structure
NEM	-	Bordetella avium

Organism

Organism	UniProt	Comment	Textmining
Bordetella avium	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-cystathionine + H2O	-	Bordetella avium	L-homocysteine + NH3 + pyruvate	-	?
L-cystine + H2O	-	Bordetella avium	L-thiocysteine + pyruvate + NH3	-	?

Cofactor

Cofactor	Comment	Organism	Structure
pyridoxal 5'-phosphate	-	Bordetella avium

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Release 2023.1 (January 2023)