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Literature summary for 4.4.1.13 extracted from
- Cysteine conjugate beta-lyase (1985), Methods Enzymol., 113, 510-515.
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.01 | - |
S-(2-benzothiazolyl)-L-cysteine | - |
Rattus norvegicus |  |
| 0.08 | - |
S-2,4-dinitrophenyl-L-cysteine | - |
Rattus norvegicus | |
| 0.1 | - |
S-1,2-dichlorovinyl-L-cysteine | - |
Rattus norvegicus | |
| 2.6 | - |
beta-chloroalanine | - |
Rattus norvegicus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.0318 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (S)-2,4-dinitrophenyl-L-cysteine | - |
Rattus norvegicus | 2,4-dinitrobenzenethiol + pyruvate + NH3 | - |
? | |
| (S)-2,4-dinitrophenyl-L-homocysteine | - |
Rattus norvegicus | ? | - |
? | |
| (S)-2-benzothiazolyl-L-cysteine | - |
Rattus norvegicus | pyruvate + NH3 + 2-mercaptobenzothiazole | - |
? | |
| (S)-4-bromophenyl-L-cysteine | - |
Rattus norvegicus | p-bromobenzenethiol + NH3 + pyruvate | - |
? | |
| (S)-4-nitrobenzyl-L-cysteine | - |
Rattus norvegicus | ? | - |
? | |
| 3-hydroxykynurenine | - |
Rattus norvegicus | ? | - |
? | |
| alanine derivatives | - |
Rattus norvegicus | ? | - |
? | |
| benzothiazolyl-L-cysteine | - |
Rattus norvegicus | ? | - |
? | |
| beta-chloroalanine | - |
Rattus norvegicus | ? | - |
? | |
| cysteine thioethers | - |
Rattus norvegicus | ? | - |
? | |
| kynurenine | - |
Rattus norvegicus | ? | - |
? | |
| additional information | cystathionine | Rattus norvegicus | ? | - |
? | |
| additional information | the 4-nitrophenylethyl, benzyl, methyl, 2-chloroethyl, butyl thioethers of cysteine | Rattus norvegicus | ? | - |
? | |
| RSH-CH2-CH(NH3+)COO- | R may represent aromatic compounds such as 4-bromobenzene and 2,4-dinitorbenzene | Rattus norvegicus | RSH + NH3 + pyruvate | - |
? | |
| S-(1,2-dichloroethenyl)-L-cysteine + H2O | - |
Rattus norvegicus | pyruvate + NH3 + dichlorovinyl mercaptane | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.8 | - |
- |
Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 9.5 | 50% of optimal activity at 7.5 and 9.5 | Rattus norvegicus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | no direct evidence for participation | Rattus norvegicus | |
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Release 2023.1 (January 2023)
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