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Literature summary for 4.4.1.11 extracted from
- Identification and functional analysis of the gene encoding methionine-gamma-lyase in Brevibacterium linens (2004), Appl. Environ. Microbiol., 70, 7348-7354.
Application
| Application | Comment | Organism |
|---|---|---|
| nutrition | the enzymatic degradation of L-methionine and subsequent formation of volatile sulfur compounds is believed to be essential for flavour development in cheese. Overproduction of Brevibacterium linens methionine-gamma-lyase in bacteria such as lactic acid bacteria can be a more efficient way to increase cheese flavour of some cheeses, among others, cheddar, than the addition of Brevibacterium linens cells or extracts, which is not successful in enhancing cheese flavour | Brevibacterium linens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expression in Escherichia coli | Brevibacterium linens |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | delta-mgl knock-out mutant, results in a 62% decrease in thiol-producing activity and a 97% decrease in total volatile sulfur compounds production | Brevibacterium linens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 43000 | - |
SDS-PAGE | Brevibacterium linens |
| 44670 | - |
calculated from amino acid sequence | Brevibacterium linens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-methionine + H2O | Brevibacterium linens | - |
methanethiol + NH3 + 2-oxobutanoate | - |
? |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Brevibacterium linens | Q5MQ31 | ATCC 9175 | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-methionine + H2O | - |
Brevibacterium linens | methanethiol + NH3 + 2-oxobutanoate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| methionine-gamma-lyase | - |
Brevibacterium linens |
| MGL | - |
Brevibacterium linens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Brevibacterium linens | |
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Release 2023.1 (January 2023)
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