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Literature summary for 4.4.1.11 extracted from
- Purification and characterization of L-methionine gamma-lyase from Brevibacterium linens BL2 (1998), Appl. Environ. Microbiol., 64, 3327-3331.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| DL-propargylglycine | - |
Brevibacterium linens |  |
| hydroxylamine | - |
Brevibacterium linens | |
| iodoacetate | - |
Brevibacterium linens | |
| Penicillamine | - |
Brevibacterium linens | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 6.12 | - |
L-methionine | - |
Brevibacterium linens | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 43000 | - |
4 * 43000, SDS-PAGE | Brevibacterium linens |
| 170000 | - |
gel filtration | Brevibacterium linens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Brevibacterium linens | - |
BL2 | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Brevibacterium linens |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| L-methionine + H2O = methanethiol + NH3 + 2-oxobutanoate | cleavage of C-N bond in addition to C-S, C-Se and C-O bond at beta-position of amino acids by elimination and replacement reactions | Brevibacterium linens |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| ethionine | - |
Brevibacterium linens | ? | - |
? | |
| L-methionine + H2O | - |
Brevibacterium linens | methanethiol + NH3 + 2-oxobutanoate | - |
? | |
| S-methyl-L-cysteine + H2O | - |
Brevibacterium linens | pyruvate + NH3 + CH3SH | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| tetramer | 4 * 43000, SDS-PAGE | Brevibacterium linens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 25 | - |
- |
Brevibacterium linens |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 5 | 50 | - |
Brevibacterium linens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.5 | 8 | - |
Brevibacterium linens |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 8 | - |
Brevibacterium linens |
pH Stability
| pH Stability | pH Stability Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 8 | stable for 24 h | Brevibacterium linens |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| pyridoxal 5'-phosphate | - |
Brevibacterium linens | |
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