Literature summary for 4.3.3.7 extracted from

Blickling, S.; Beisel, H.G.; Bozic, D.; Knaeblein, J.; Laber, B.; Huber, R.
Structure of dihydrodipicolinate synthase of Nicotiana sylvestris reveals novel quaternary structure (1997), J. Mol. Biol., 274, 608-621.

Search for more literature for 4.3.3.7

Crystallization (Commentary)

Crystallization (Comment)	Organism
crystal structure at 2.8 A resolution	Nicotiana sylvestris

Inhibitors

Inhibitors	Comment	Organism	Structure
L-lysine	discussion of plant inhibition versus bacterial inhibition	Nicotiana sylvestris

Organism

Organism	UniProt	Comment	Textmining
Nicotiana sylvestris	-	tobacco	-

Reaction

Reaction	Comment	Organism	Reaction ID
pyruvate + L-aspartate-4-semialdehyde = (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinate + H2O	the reaction is initiated by an nucleophilic attack of the epsilon-amino group of active site lysine to the C2 atom of pyruvate with subsequent imine formation. Tautomerization of the imine to the enamine creates the nucleophile necessary for the attack of the aldehyde group of L-aspartate semialdehyde. Cyclization of the substrate coupled with transamination leads to stepwise detachment from the active site	Nicotiana sylvestris	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-aspartate-4-semialdehyde + pyruvate	-	Nicotiana sylvestris	dihydrodipicolinate + H2O	(4S)-4-hydroxy-2,3,4,5-terahydro-(2S)-dipicolinic acid is the initial but instable product	?

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)