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Literature summary for 4.3.2.5 extracted from

  • Ping, D.; Mounier, C.E.; May, S.W.
    Reaction versus subsite stereospecificity of peptidylglycine alpha-monooxygenase and peptidylamidoglycolate lyase, the two enzymes involved in peptide amidation (1995), J. Biol. Chem., 270, 29250-29255.
    View publication on PubMed
Search for more literature for 4.3.2.5

Inhibitors

Inhibitors Comment Organism Structure
(R)-2-phenylbutyl-alpha-hydroxy-Gly
-
 Bos taurus
(S)-2-phenylbutyl-alpha-hydroxy-Gly
-
 Bos taurus
phenylacetyl-alpha-hydroxy-Gly competitive inhibition Bos taurus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.027
-
 trinitrophenyl-D-Tyr-L-Val-alpha-hydroxy-Gly 37°C, pH 6.5 Bos taurus
0.23
-
 acetyl-L-Phe-alpha-hydroxyglycine 37°C, pH 6.5 Bos taurus
0.3
-
 (R)-2-phenylbutyl-alpha-hydroxy-Gly 37°C, pH 6.5 Bos taurus
0.33
-
 (S)-2-phenylbutyl-alpha-hydroxy-Gly 37°C, pH 6.5 Bos taurus
0.46
-
 N-benzoyl-alpha-hydroxy-Gly 37°C, pH 6.5 Bos taurus
0.5
-
 acetyl-D-Phe-alpha-hydroxyglycine 37°C, pH 6.5 Bos taurus
0.56
-
 (S)-O-acetyl-mandelyl-alpha-hydroxyglycine 37°C, pH 6.5 Bos taurus
2.6
-
 (R)-O-acetyl-mandelyl-alpha-hydroxyglycine 37°C, pH 6.5 Bos taurus

Organism

Organism UniProt Comment Textmining
Bos taurus
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Bos taurus

Source Tissue

Source Tissue Comment Organism Textmining
pituitary gland
-
 Bos taurus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(R)-2-phenylbutyl-alpha-hydroxy-Gly
-
 Bos taurus (R)-2-phenylbutyl-NH2 + glyoxylate
-
 ?
(R)-O-acetyl-mandelyl-alpha-hydroxyglycine
-
 Bos taurus (R)-O-acetyl-mandelyl-NH2 + glyoxylate
-
 ?
(S)-2-phenylbutyl-alpha-hydroxy-Gly
-
 Bos taurus (S)-2-phenylbutyl-NH2 + glyoxylate
-
 ?
(S)-O-acetyl-mandelyl-alpha-hydroxyglycine
-
 Bos taurus (S)-O-acetyl-mandelyl-NH2 + glyoxylate
-
 ?
acetyl-D-Phe-alpha-hydroxyglycine
-
 Bos taurus acetyl-D-Phe-NH2 + glyoxylate
-
 ?
acetyl-L-Phe-alpha-hydroxyglycine
-
 Bos taurus acetyl-L-Phe-NH2 + glyoxylate
-
 ?
N-benzoyl-alpha-hydroxy-Gly
-
 Bos taurus benzamide + glyoxylate
-
 ?
trinitrophenyl-D-Tyr-L-Val-alpha-hydroxy-Gly
-
 Bos taurus trinitrophenyl-D-Tyr-L-Val-NH2 + glyoxylate
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.28
-
 (S)-2-phenylbutyl-alpha-hydroxy-Gly 37°C, pH 6.5 Bos taurus
0.31
-
 (R)-2-phenylbutyl-alpha-hydroxy-Gly 37°C, pH 6.5 Bos taurus
0.77
-
 phenylacetyl-alpha-hydroxy-Gly 37°C, pH 6.5 Bos taurus