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Literature summary for 4.3.2.2 extracted from
- Adenylosuccinate lyase deficiency (2006), Mol. Genet. Metab., 89, 19-31.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | adenylosuccinate lyase deficiency causes serious neurological and physiological symptoms | Mus musculus |
| medicine | adenylosuccinate lyase deficiency causes serious neurological and physiological symptoms | Homo sapiens |
Crystallization (Commentary)
| Crystallization (Comment) | Organism |
|---|---|
| at a resolution of 1.8 A | Thermotoga maritima |
| at a resolution of 2.1 A | Pyrobaculum aerophilum |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| additional information | the review gives an overview of the characteristics of patients with ADSL deficiency in dependence of amino acid changes | Homo sapiens |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 52000 | - |
monomer | Bacillus subtilis |
| 52000 | - |
monomer | Mus musculus |
| 52000 | - |
monomer | Homo sapiens |
| 52000 | - |
monomer | Pyrobaculum aerophilum |
| 52000 | - |
monomer | Thermotoga maritima |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate | Bacillus subtilis | - |
fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide | - |
? |  |
| (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate | Mus musculus | - |
fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide | - |
? | |
| (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate | Homo sapiens | - |
fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide | - |
? | |
| (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate | Pyrobaculum aerophilum | - |
fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide | - |
? | |
| (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate | Thermotoga maritima | - |
fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide | - |
? | |
| N6-(1,2-dicarboxyethyl)AMP | Bacillus subtilis | - |
fumarate + AMP | - |
? | |
| N6-(1,2-dicarboxyethyl)AMP | Mus musculus | - |
fumarate + AMP | - |
? | |
| N6-(1,2-dicarboxyethyl)AMP | Homo sapiens | - |
fumarate + AMP | - |
? | |
| N6-(1,2-dicarboxyethyl)AMP | Pyrobaculum aerophilum | - |
fumarate + AMP | - |
? | |
| N6-(1,2-dicarboxyethyl)AMP | Thermotoga maritima | - |
fumarate + AMP | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus subtilis | - |
- |
- |
| Homo sapiens | - |
- |
- |
| Mus musculus | - |
- |
- |
| Pyrobaculum aerophilum | - |
- |
- |
| Thermotoga maritima | Q9X0I0 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate | - |
Bacillus subtilis | fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide | - |
? | |
| (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate | - |
Mus musculus | fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide | - |
? | |
| (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate | - |
Homo sapiens | fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide | - |
? | |
| (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate | - |
Pyrobaculum aerophilum | fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide | - |
? | |
| (S)-2-[5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido]succinate | - |
Thermotoga maritima | fumarate + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide | - |
? | |
| 5-aminoimidazole-(N-succinylocarboxamide) ribotide | - |
Bacillus subtilis | 5-aminoimidazole-4-carboxamide ribotide + fumarate | - |
? | |
| 5-aminoimidazole-(N-succinylocarboxamide) ribotide | - |
Mus musculus | 5-aminoimidazole-4-carboxamide ribotide + fumarate | - |
? | |
| 5-aminoimidazole-(N-succinylocarboxamide) ribotide | - |
Homo sapiens | 5-aminoimidazole-4-carboxamide ribotide + fumarate | - |
? | |
| 5-aminoimidazole-(N-succinylocarboxamide) ribotide | - |
Pyrobaculum aerophilum | 5-aminoimidazole-4-carboxamide ribotide + fumarate | - |
? | |
| 5-aminoimidazole-(N-succinylocarboxamide) ribotide | - |
Thermotoga maritima | 5-aminoimidazole-4-carboxamide ribotide + fumarate | - |
? | |
| adenylosuccinate | - |
Bacillus subtilis | AMP + fumarate | - |
? | |
| adenylosuccinate | - |
Mus musculus | AMP + fumarate | - |
? | |
| adenylosuccinate | - |
Homo sapiens | AMP + fumarate | - |
? | |
| adenylosuccinate | - |
Pyrobaculum aerophilum | AMP + fumarate | - |
? | |
| adenylosuccinate | - |
Thermotoga maritima | AMP + fumarate | - |
? | |
| N6-(1,2-dicarboxyethyl)AMP | - |
Bacillus subtilis | fumarate + AMP | - |
? | |
| N6-(1,2-dicarboxyethyl)AMP | - |
Mus musculus | fumarate + AMP | - |
? | |
| N6-(1,2-dicarboxyethyl)AMP | - |
Homo sapiens | fumarate + AMP | - |
? | |
| N6-(1,2-dicarboxyethyl)AMP | - |
Pyrobaculum aerophilum | fumarate + AMP | - |
? | |
| N6-(1,2-dicarboxyethyl)AMP | - |
Thermotoga maritima | fumarate + AMP | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| homotetramer | - |
Bacillus subtilis |
| homotetramer | - |
Mus musculus |
| homotetramer | - |
Homo sapiens |
| homotetramer | - |
Pyrobaculum aerophilum |
| homotetramer | - |
Thermotoga maritima |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| adenylosuccinate lyase | - |
Bacillus subtilis |
| adenylosuccinate lyase | - |
Mus musculus |
| adenylosuccinate lyase | - |
Homo sapiens |
| adenylosuccinate lyase | - |
Pyrobaculum aerophilum |
| adenylosuccinate lyase | - |
Thermotoga maritima |
| ADSL | - |
Bacillus subtilis |
| ADSL | - |
Mus musculus |
| ADSL | - |
Homo sapiens |
| ADSL | - |
Pyrobaculum aerophilum |
| ADSL | - |
Thermotoga maritima |
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Release 2023.1 (January 2023)
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