Application | Comment | Organism |
---|---|---|
medicine | manipulating the enzyme expression or activity might be of potential benefit for treatment of necrotizing enterocolitis | Mus musculus |
medicine | manipulating the enzyme expression or activity might be of potential benefit for treatment of necrotizing enterocolitis | Rattus norvegicus |
Protein Variants | Comment | Organism |
---|---|---|
additional information | generation of enterocyte-specific knockout mice of the enzyme Asl by intercrossing Aslflox/flox mice with transgenic mice expressing Cre recombinase under the control of the villin promoter. Emgineered mice are grossly indistinguishable from their littermate Aslflox/flox controls and exhibit similar growth curves and life span. Enterocytes isolated from mutant mice demonstrate an 80% reduction in mRNA expression of the enzyme | Mus musculus |
additional information | knock-down of enzyme Asl in IEC-6 cells using lentivirus encoding shRNA targeting the enzyme. Loss of the enzyme impairs the migration of IEC-6 cells during conditions of stress | Rattus norvegicus |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | - |
- |
- |
Rattus norvegicus | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
enterocyte | - |
Mus musculus | - |
enterocyte | - |
Rattus norvegicus | - |
IEC-6 cell | - |
Rattus norvegicus | - |
ileum | - |
Mus musculus | - |
ileum | - |
Rattus norvegicus | - |
intestine | intestinal segments from neonatal pups | Mus musculus | - |
intestine | intestinal segments from neonatal pups | Rattus norvegicus | - |
General Information | Comment | Organism |
---|---|---|
malfunction | loss of enterocyte-derived enzyme results in increased incidence of necrotizing enterocolitis, phenotype, overview | Mus musculus |
malfunction | loss of enterocyte-derived enzyme results in increased incidence of necrotizing enterocolitis, phenotype, overview | Rattus norvegicus |
physiological function | argininosuccinate lyase in enterocytes protects from development of necrotizing enterocolitis, cell-autonomous role of the enzyme. The enzyme is required to maintain a NO synthesis complex containing NO synthase, argininosuccinate synthase, HSP90, and the arginine transporter SLC7A1 | Mus musculus |
physiological function | argininosuccinate lyase in enterocytes protects from development of necrotizing enterocolitis, cell-autonomous role of the enzyme. The enzyme is required to maintain a NO synthesis complex containing NO synthase, argininosuccinate synthase, HSP90, and the arginine transporter SLC7A1 | Rattus norvegicus |