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Literature summary for 4.3.1.3 extracted from
- A role for ultraviolet radiation immunosuppression in non-melanoma skin cancer as evidenced by gene-environment interactions (2008), Carcinogenesis, 29, 1950-1954.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| estrogen | transcriptional activator of histidase expression | Homo sapiens |  |
| glucocorticoid | transcriptional activator of histidase expression | Homo sapiens |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-histidine | Homo sapiens | enzyme catalyzes the formation of urocanic acid in the skin, modifies risk of basal cell carcinoma and squamous cell carcinoma | trans-urocanic acid + NH3 | urocanic acid is a UV radiation-absorbing molecule in the stratum corneum | ? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| lymphocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-histidine | enzyme catalyzes the formation of urocanic acid in the skin, modifies risk of basal cell carcinoma and squamous cell carcinoma | Homo sapiens | trans-urocanic acid + NH3 | urocanic acid is a UV radiation-absorbing molecule in the stratum corneum | ? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| HAL | - |
Homo sapiens |
| histidase | - |
Homo sapiens |
| histidine ammonia-lyase | - |
Homo sapiens |
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