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Literature summary for 4.3.1.3 extracted from
- Histidine ammonia-lyase from rat liver. Purification, properties, and inhibition by substrate analogues (1976), Biochemistry, 15, 1814-1821.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-nitro-L-histidine | competitive | Pseudomonas fluorescens |  |
| 5-fluoro-L-histidine | competitive | Pseudomonas fluorescens | |
| D-alpha-hydrazinoimidazolylpropionic acid | strong | Rattus norvegicus | |
| D-histidine | competitive | Pseudomonas fluorescens | |
| D-histidine | competitive | Rattus norvegicus | |
| DL-pyrazolyl-3-alanine | 5.0 mM | Rattus norvegicus | |
| glycine | - |
Rattus norvegicus | |
| L-1-methylhistidine | 5.0 mM | Rattus norvegicus | |
| L-alanine | 5.0 mM | Rattus norvegicus | |
| L-histidine hydroxamate | competitive; strong | Rattus norvegicus | |
| L-histidinemethyl ester | 5.0 mM | Rattus norvegicus | |
| L-histidinol | competitive | Rattus norvegicus | |
| additional information | - |
Rattus norvegicus | |
| N-acetyl-L-histidine | 5.0 mM | Rattus norvegicus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Rattus norvegicus | |
| additional information | - |
additional information | - |
Pseudomonas fluorescens | |
| 0.45 | - |
L-histidine | pH 9.0 | Rattus norvegicus | |
| 2.1 | - |
L-histidine | pH 7.2 | Rattus norvegicus | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 203000 | - |
disc gel electrophoresis | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pseudomonas fluorescens | - |
- |
- |
| Rattus norvegicus | - |
Holtzman albion rat | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Rattus norvegicus |
Reaction
| Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|
| L-histidine = urocanate + NH3 | mechanism | Rattus norvegicus | |
| L-histidine = urocanate + NH3 | mechanism | Pseudomonas fluorescens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 9.94 | - |
- |
Rattus norvegicus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-fluorohistidine | - |
Pseudomonas fluorescens | 4-fluorourocanate + NH3 | - |
? | |
| 4-nitro-L-histidine | - |
Pseudomonas fluorescens | 4-nitrourocanate + NH3 | - |
? | |
| L-histidine | natural substrate | Rattus norvegicus | urocanate + NH3 | - |
? | |
| L-histidine | natural substrate | Pseudomonas fluorescens | urocanate + NH3 | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8.5 | - |
- |
Rattus norvegicus |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 6.5 | 10 | inactive below pH 6.5, 75% of maximal activity at pH 10.0 | Rattus norvegicus |
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