Protein Variants | Comment | Organism |
---|---|---|
C503S/C565S | the mutant shows high protein stability and is very efficient as protein therapeutics in treatment of phenylketonuria, PKU, with lowered phenylalanine levels in both vascular space and brain tissue over a 90 day trial period, resulting in reduced manifestations associated with PKU, including reversal of PKU-associated hypopigmentation and enhanced animal health in a mouse model, the wild-type enzyme is less efective, overview | Trichormus variabilis |
R91K | the mutant shows increased activity compared to the wild-type enzyme | Trichormus variabilis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-phenylalanine | Trichormus variabilis | - |
(E)-cinnamate + NH3 | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Trichormus variabilis | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
L-phenylalanine | - |
Trichormus variabilis | (E)-cinnamate + NH3 | - |
? |
Synonyms | Comment | Organism |
---|---|---|
PAL | - |
Trichormus variabilis |