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Literature summary for 4.3.1.24 extracted from

  • Ma, L.Q.; Gao, D.Y.; Wang, Y.N.; Wang, H.H.; Zhang, J.X.; Pang, X.B.; Hu, T.S.; Lue, S.Y.; Li, G.F.; Ye, H.C.; Li, Y.F.; Wang, H.
    Effects of overexpression of endogenous phenylalanine ammonia-lyase (PALrs1) on accumulation of salidroside in Rhodiola sachalinensis (2008), Plant Biol., 10, 323-333.
    View publication on PubMed
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Application

Application Comment Organism
synthesis the enzyme is involved in and useful for production salidroside, an effective adaptogenic drug from the medicinal plant Rhodiola sachalinensis Rhodiola sachalinensis

Cloned(Commentary)

Cloned (Comment) Organism
gene PALrs1, DNA and amino acid sequence determination and analysis, and analysis of egenomic structure, overview. Expression of PALrs1 under the 35S promoter with double-enhancer sequences from CaMV-W and TMV-W fragments in Rhodiola sachalinensis via Agrobacterium tumefaciens transfection method Rhodiola sachalinensis

Protein Variants

Protein Variants Comment Organism
additional information overexpression of the PALrs1 gene in Rhodiola sachalinensis plants results in a 3.3fold increase in 4-coumaric acid content, while levels of tyrosol and salidroside are 4.7fold and 7.7fold, respectively, lower in PALrs1 transgenic plants than in controls Rhodiola sachalinensis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
77450
-
 x * 77450, PALrs1, sequence calcualtion Rhodiola sachalinensis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-phenylalanine Rhodiola sachalinensis the enzyme is involved in the biosynthesis of salidroside, an effective adaptogenic drug extracted from the medicinal plant Rhodiola sachalinensis, two different possible biosynthetic pathways via tyrosol, overview (E)-cinnamate + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Rhodiola sachalinensis Q5EIB6 PALrs1; gene PALrs1
-

Source Tissue

Source Tissue Comment Organism Textmining
callus
-
 Rhodiola sachalinensis
-
leaf
-
 Rhodiola sachalinensis
-
root low expression level Rhodiola sachalinensis
-
stem
-
 Rhodiola sachalinensis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-phenylalanine
-
 Rhodiola sachalinensis (E)-cinnamate + NH3
-
 ?
L-phenylalanine the enzyme is involved in the biosynthesis of salidroside, an effective adaptogenic drug extracted from the medicinal plant Rhodiola sachalinensis, two different possible biosynthetic pathways via tyrosol, overview Rhodiola sachalinensis (E)-cinnamate + NH3
-
 ?

Subunits

Subunits Comment Organism
? x * 77450, PALrs1, sequence calcualtion Rhodiola sachalinensis

Synonyms

Synonyms Comment Organism
PALrs1
-
 Rhodiola sachalinensis

pI Value

Organism Comment pI Value Maximum pI Value
Rhodiola sachalinensis sequence calcualtion
-
 6.5