Literature summary for 4.3.1.24 extracted from

Pilbak, S.; Tomin, A.; Retey, J.; Poppe, L.
The essential tyrosine-containing loop conformation and the role of the C-terminal multi-helix region in eukaryotic phenylalanine ammonia-lyases (2006), FEBS J., 273, 1004-1019.

Search for more literature for 4.3.1.24

Crystallization (Commentary)

Crystallization (Comment)	Organism
homology modeling of structure. The active state of enzyme is a Tyr110-loop-in conformation and opening-closing the entrance to the active site may happen by a breathing motion of this loop. Comparison with strucutural models of Photorhabdus luminescens and Streptomyces maritimus enzymes	Petroselinum crispum
molecular dynamics studies. The Tyr61-loop-in model is conformationally stable and assumed to be the active form. Deletion of the C-terminal multi-helix domain results in a significantly more rigid Tyr-loop-in structure. Comparison with strucutural models of Petroselinum crispum and Photorhabdus luminescens enzymes	Streptomyces maritimus
molecular dynamics studies. The Tyr61-loop-in model is conformationally stable and assumed to be the active form. Deletion of the C-terminal multi-helix domain results in a significantly more rigid Tyr-loop-in structure. Comparison with strucutural models of Petroselinum crispum and Streptomyces maritimus enzymes	Photorhabdus luminescens

Protein Variants

Protein Variants	Comment	Organism
additional information	a Tyr10-loop-in conformation of the enzyme structure is constructed by partial homology modeling, and the static and dynamic behavior of the loop-in/loop-out structures are compared	Petroselinum crispum
additional information	building of Tyr-loop-in/loop-out model structure lacking the C-terminal domain	Photorhabdus luminescens
additional information	building of Tyr-loop-in/loop-out model structure lacking the C-terminal domain	Streptomyces maritimus

Organism

Organism	UniProt	Comment	Textmining
Petroselinum crispum	P24481	-	-
Photorhabdus luminescens	-	-	-
Streptomyces maritimus	-	-	-

Cofactor

Cofactor	Comment	Organism	Structure
3,5-dihydro-5-methylidene-4H-imidazol-4-one	MIO cofactor	Photorhabdus luminescens
3,5-dihydro-5-methylidene-4H-imidazol-4-one	MIO cofactor	Streptomyces maritimus
3,5-dihydro-5-methylidene-4H-imidazol-4-one	MIO cofactor	Petroselinum crispum

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Release 2023.1 (January 2023)