Literature summary for 4.3.1.24 extracted from

Viergutz, S.; Poppe, L.; Tomin, A.; Retey, J.
Mechanistic investigation of phenylalanine ammonia lyase by using N-methylated phenylalanines (2003), Helv. Chim. Acta, 86, 3601-3612.

No PubMed abstract available

Search for more literature for 4.3.1.24

Inhibitors

Inhibitors	Comment	Organism	Structure
N,N-dimethyl-4-nitro-L-phenylalanine	-	Petroselinum crispum
N-methyl-4-nitro-L-phenylalanine	-	Petroselinum crispum

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
2.6	-	NH3	pH 10.0	Petroselinum crispum
4.4	-	NH3	pH 8.8	Petroselinum crispum
6.6	-	N-methyl-L-phenylalanine	-	Petroselinum crispum

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
L-phenylalanine	Petroselinum crispum	-	(E)-cinnamate + NH3	-	r

Organism

Organism	UniProt	Comment	Textmining
Petroselinum crispum	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
L-phenylalanine	-	Petroselinum crispum	(E)-cinnamate + NH3	-	?
L-phenylalanine	-	Petroselinum crispum	(E)-cinnamate + NH3	-	r
N-methyl-L-phenylalanine	-	Petroselinum crispum	trans-cinnamate + methylamine	-	?

Turnover Number [1/s]

Turnover Number Minimum [1/s]	Turnover Number Maximum [1/s]	Substrate	Comment	Organism	Structure
0.22	-	N-methyl-L-phenylalanine	-	Petroselinum crispum

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.000008	-	N,N-dimethyl-4-nitro-L-phenylalanine	-	Petroselinum crispum
0.00013	-	N-methyl-4-nitro-L-phenylalanine	-	Petroselinum crispum

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Release 2023.1 (January 2023)