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Literature summary for 4.3.1.19 extracted from

  • Risso, C.; Van Dien, S.J.; Orloff, A.; Lovley, D.R.; Coppi, M.V.
    Elucidation of an alternate isoleucine biosynthesis pathway in Geobacter sulfurreducens (2008), J. Bacteriol., 190, 2266-2274.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.3.1.19

Cloned(Commentary)

Cloned (Comment) Organism
gene tcdB, phylogenetic analysis of threonine ammonia-lyases Geobacter sulfurreducens

Inhibitors

Inhibitors Comment Organism Structure
additional information TcdB is not inhibited by isoleucine Geobacter sulfurreducens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-threonine Geobacter sulfurreducens a step in the pathway for the biosynthesis of isoleucine via isoleucine precursor 2-oxobutanoate generated from threonine, this pathway accounts for a minor fraction of isoleucine biosynthesis, while the majority of isoleucine is instead derived from acetyl-coenzyme A and pyruvate, possibly via the citramalate pathway, overview 2-oxobutanoate + NH3
-
 ?
L-threonine Geobacter sulfurreducens DSM 12127 a step in the pathway for the biosynthesis of isoleucine via isoleucine precursor 2-oxobutanoate generated from threonine, this pathway accounts for a minor fraction of isoleucine biosynthesis, while the majority of isoleucine is instead derived from acetyl-coenzyme A and pyruvate, possibly via the citramalate pathway, overview 2-oxobutanoate + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Geobacter sulfurreducens Q74FW6 strain DL-1, ATCC 51573, gene GSU0486 or tcdB
-
Geobacter sulfurreducens DSM 12127 Q74FW6 strain DL-1, ATCC 51573, gene GSU0486 or tcdB
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
0.189
-
 strain DL-1 Geobacter sulfurreducens

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-threonine
-
 Geobacter sulfurreducens 2-oxobutanoate + NH3
-
 ?
L-threonine a step in the pathway for the biosynthesis of isoleucine via isoleucine precursor 2-oxobutanoate generated from threonine, this pathway accounts for a minor fraction of isoleucine biosynthesis, while the majority of isoleucine is instead derived from acetyl-coenzyme A and pyruvate, possibly via the citramalate pathway, overview Geobacter sulfurreducens 2-oxobutanoate + NH3
-
 ?
L-threonine
-
 Geobacter sulfurreducens DSM 12127 2-oxobutanoate + NH3
-
 ?
L-threonine a step in the pathway for the biosynthesis of isoleucine via isoleucine precursor 2-oxobutanoate generated from threonine, this pathway accounts for a minor fraction of isoleucine biosynthesis, while the majority of isoleucine is instead derived from acetyl-coenzyme A and pyruvate, possibly via the citramalate pathway, overview Geobacter sulfurreducens DSM 12127 2-oxobutanoate + NH3
-
 ?
additional information GSU0486 also catalyzes the deamination of L-serine, EC 4.3.1.17 Geobacter sulfurreducens ?
-
 ?
additional information GSU0486 also catalyzes the deamination of L-serine, EC 4.3.1.17 Geobacter sulfurreducens DSM 12127 ?
-
 ?

Synonyms

Synonyms Comment Organism
GSU0486
-
 Geobacter sulfurreducens
tdcB
-
 Geobacter sulfurreducens
Thr ammonia-lyase
-
 Geobacter sulfurreducens
threonine ammonia-lyase
-
 Geobacter sulfurreducens