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Literature summary for 4.3.1.18 extracted from

  • Shleper, M.; Kartvelishvily, E.; Wolosker, H.
    D-Serine is the dominant endogenous coagonist for NMDA receptor neurotoxicity in organotypic hippocampal slices (2005), J. Neurosci., 25, 9413-9417.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
degradation the enzyme is applied to remove endogenous D-serine from organotypic hippocampal slices. Complete removal of D-serine virtually abolishes NMDA-elicited neurotoxicity Escherichia coli

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.1
-
D-serine
-
Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
D-serine Escherichia coli
-
pyruvate + NH3
-
?
D-serine Escherichia coli CFT073
-
pyruvate + NH3
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
recombinant enzyme
-
Escherichia coli CFT073
-
recombinant enzyme
-

Purification (Commentary)

Purification (Comment) Organism
to homogeneity Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-serine
-
Escherichia coli pyruvate + NH3
-
?
D-serine
-
Escherichia coli CFT073 pyruvate + NH3
-
?

Synonyms

Synonyms Comment Organism
D-Serine deaminase
-
Escherichia coli
DsdA
-
Escherichia coli

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
15.7
-
D-serine
-
Escherichia coli