Literature summary for 4.3.1.17 extracted from

Zhang, X.; El-Hajj, Z.W.; Newman, E.
Deficiency in L-serine deaminase interferes with one-carbon metabolism and cell wall synthesis in Escherichia coli K-12 (2010), J. Bacteriol., 192, 5515-5525.

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Localization

Localization	Comment	Organism	GeneOntology No.	Textmining

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	P16095	-	-
Escherichia coli	P30744	-	-
Escherichia coli	P42630	-	-

Synonyms

Synonyms	Comment	Organism
L-serine deaminase 2	-	Escherichia coli
L-serine dehydratase 1	-	Escherichia coli
L-serine dehydratase 2	-	Escherichia coli
SdaA	-	Escherichia coli
SdaB	-	Escherichia coli
SDH1	-	Escherichia coli
SDH2	-	Escherichia coli
TdcG	-	Escherichia coli

General Information

General Information	Comment	Organism
physiological function	Escherichia coli K-12 provided with glucose and a mixture of amino acids depletes L-serine more quickly than any other amino acid even in the presence of ammonium sulfate. A mutant lacking 4Fe4S L-serine deaminases SdaA, SdaB, and TdcG is unable to do this. The high level of L-serine that accumulates when the mutant is exposed to amino acid mixtures starves the cells for C1 units and interferes with cell wall synthesis. Growth in minimal medium containing glucose, ammonium sulfate, and Casamino Acids results in deformed cells and frequently lysing, which can be reversed by adding S-adenosylmethionine	Escherichia coli

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Release 2023.1 (January 2023)