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Literature summary for 4.3.1.17 extracted from

  • Foltyn, V.N.; Bendikov, I.; De Miranda, J.; Panizzutti, R.; Dumin, E.; Shleper, M.; Li, P.; Toney, M.D.; Kartvelishvily, E.; Wolosker, H.
    Serine racemase modulates intracellular D-serine levels through an alpha,beta-elimination activity (2005), J. Biol. Chem., 280, 1754-1763.
    View publication on PubMed
Search for more literature for 4.3.1.17

Activating Compound

Activating Compound Comment Organism Structure
ATP
-
 Mus musculus

Protein Variants

Protein Variants Comment Organism
H152S ratio of elimination reaction to racemization is 1.4 compared to 3.7 in wild-type Mus musculus
N154F ratio of elimination reaction to racemization is 0.33 compared to 3.7 in wild-type Mus musculus
P153S ratio of elimination reaction to racemization is 0.24 compared to 3.7 in wild-type Mus musculus
Q155D ratio of elimination reaction to racemization is 0.25 compared to 3.7 in wild-type Mus musculus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
8.5
-
 D-serine wild-type, alpha,beta-elimination, pH 7.4, 37°C Mus musculus
9
-
 L-serine wild-type, alpha,beta-elimination, pH 7.4, 37°C Mus musculus
9
-
 D-serine wild-type, alpha,beta-elimination, presence of ATP, pH 7.4, 37°C Mus musculus
10
-
 L-serine wild-type, alpha,beta-elimination, presence of ATP, pH 7.4, 37°C Mus musculus
11
-
 L-serine mutant Q155D, alpha,beta-elimination, presence of ATP, pH 7.4, 37°C Mus musculus
12
-
 D-serine mutant Q155D, alpha,beta-elimination, presence of ATP, pH 7.4, 37°C Mus musculus
55
-
 D-threonine wild-type, alpha,beta-elimination, presence of ATP, pH 7.4, 37°C Mus musculus
60
-
 D-threonine mutant Q155D, alpha,beta-elimination, presence of ATP, pH 7.4, 37°C Mus musculus

Organism

Organism UniProt Comment Textmining
Mus musculus
-
 bifunctional enzymes, racemization of serine and alpha,beta-elimination of L-serine
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-serine alpha,beta-elimination reaction Mus musculus pyruvate + NH3
-
 ?
D-serine racemization reaction Mus musculus L-serine
-
 r
D-threonine
-
 Mus musculus 2-oxobutyrate + NH3
-
 ?
L-serine alpha,beta-elimination reaction Mus musculus pyruvate + NH3
-
 ?
L-serine racemization reaction Mus musculus D-serine
-
 r
L-threonine alpha,beta-elimination reaction Mus musculus 2-oxobutyrate + NH3
-
 ?
additional information ration of elimination reaction/racemization reaction for substrate L-serine is 3.7 Mus musculus ?
-
 ?

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.0033
-
 D-serine wild-type, pH 7.4, 37°C Mus musculus
0.012
-
 D-serine mutant Q155D, alpha,beta-elimination, presence of ATP, pH 7.4, 37°C Mus musculus
0.028
-
 D-threonine mutant Q155D, alpha,beta-elimination, presence of ATP, pH 7.4, 37°C Mus musculus
0.033
-
 L-serine mutant Q155D, presence of ATP, pH 7.4, 37°C Mus musculus
0.033
-
 L-serine wild-type, alpha,beta-elimination, pH 7.4, 37°C Mus musculus
0.042
-
 D-serine wild-type, alpha,beta-elimination, presence of ATP, pH 7.4, 37°C Mus musculus
0.166
-
 L-serine wild-type, alpha,beta-elimination, presence of ATP, pH 7.4, 37°C Mus musculus
0.3
-
 D-threonine wild-type, alpha,beta-elimination, presence of ATP, pH 7.4, 37°C Mus musculus