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Literature summary for 4.2.99.18 extracted from

  • Broxson, C.; Hayner, J.N.; Beckett, J.; Bloom, L.B.; Tornaletti, S.
    Human AP endonuclease inefficiently removes abasic sites within G4 structures compared to duplex DNA (2014), Nucleic Acids Res., 42, 7708-7719.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
analysis development an effective in vitro system for monitoring G quadruplex structure formation in damage-containing DNA, a tool to investigate the mechanistic details of repair occurring at this noncanonical DNA structure Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
additional information the presence within the G quadruplex DNA structure of an abasic site decreases the efficiency of human AP endonuclease activity. This effect is mostly the result of a decreased enzymatic activity and not of decreased binding of the enzyme to the damaged site Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
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