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Literature summary for 4.2.99.18 extracted from
- Identification of apurinic/apyrimidinic endonuclease 1 (APE1) as the endoribonuclease that cleaves c-myc mRNA (2009), Nucleic Acids Res., 37, 3946-3958.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| expressed in Escherichia coli BL21(DE3) cells | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| polysome | - |
Rattus norvegicus | 5844 | - |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 35000 | - |
native enzyme, SDS-PAGE | Homo sapiens |
| 35000 | - |
native enzyme, SDS-PAGE | Rattus norvegicus |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
| Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| heparin-Sepharose column chromatography and Superdex 75 gel filtration | Rattus norvegicus |
| Ni-NTA column chromatography and Superdex 75 gel filtration | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| HeLa cell | - |
Homo sapiens | - |
| liver | - |
Rattus norvegicus | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| c-myc coding region determinant mRNA | APE1 preferentially cleaves in between UA and CA dinucleotides of c-myc coding region determinant RNA | Homo sapiens | ? | - |
? |  |
| c-myc coding region determinant mRNA | APE1 preferentially cleaves in between UA and CA dinucleotides of c-myc coding region determinant RNA | Rattus norvegicus | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| AP DNA endonuclease 1 | - |
Homo sapiens |
| AP DNA endonuclease 1 | - |
Rattus norvegicus |
| APE1 | - |
Homo sapiens |
| APE1 | - |
Rattus norvegicus |
| apurinic/apyrimidinic DNA endonuclease 1 | - |
Homo sapiens |
| apurinic/apyrimidinic DNA endonuclease 1 | - |
Rattus norvegicus |
| Ref-1 | - |
Homo sapiens |
| Ref-1 | - |
Rattus norvegicus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | APE1 regulates c-myc mRNA level possibly via its endoribonuclease activity | Homo sapiens |
| physiological function | APE1 regulates c-myc mRNA level possibly via its endoribonuclease activity | Rattus norvegicus |
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Release 2023.1 (January 2023)
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