Inhibitors | Comment | Organism | Structure |
---|---|---|---|
E3330 | binds specifically to Ape1/Ref-1 and blocks its redox activity | Homo sapiens | |
additional information | methoxyamine binds to and occludes abasic sites in DNA and thereby inhibits Ape1/Ref-1-mediated DNA repair | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
MCF-7 cell | - |
Homo sapiens | - |
U2-OS cell | - |
Homo sapiens | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
DNA | - |
Homo sapiens | fragments of DNA | - |
? |
Synonyms | Comment | Organism |
---|---|---|
APE1 | - |
Homo sapiens |
apurinic/apyrimidinic endonuclease 1 | - |
Homo sapiens |
redox factor-1 | - |
Homo sapiens |
Ref-1 | - |
Homo sapiens |
General Information | Comment | Organism |
---|---|---|
malfunction | knocking down Ape1/Ref-1 expression enhances estrogen responsiveness of the progesterone receptor and pS2 genes but does not alter the expression of the constitutively active 36B4 gene | Homo sapiens |
physiological function | Ape1/Ref-1 enhances the interaction of estrogen receptor alpha with estrogen-response elements in DNA, Ape1/Ref-1 alters expression of the endogenous, estrogen-responsive progesterone receptor and pS2 genes in MCF-7 cells and associates with estrogen-response elements-containing regions of these genes in native chromatin | Homo sapiens |