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Literature summary for 4.2.99.18 extracted from

  • Peddi, S.R.; Chattopadhyay, R.; Naidu, C.V.; Izumi, T.
    The human apurinic/apyrimidinic endonuclease-1 suppresses activation of poly(adp-ribose) polymerase-1 induced by DNA single strand breaks (2006), Toxicology, 224, 44-55.
    View publication on PubMed
Search for more literature for 4.2.99.18

Cloned(Commentary)

Cloned (Comment) Organism
into the pET15b vector for expression in Escherichia coli Homo sapiens

Protein Variants

Protein Variants Comment Organism
R177A APE1's high affinity for DNA single-strand breaks requires Arg177, poly(ADP-ribose)polymerase 1, PARP1, activation is not suppressed by the mutant Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ APE1 binds to AP sites in the absence of Mg2+, a condition in which APE1 does not have endonuclease activity Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens P27695
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Homo sapiens

Synonyms

Synonyms Comment Organism
APE1
-
 Homo sapiens
apurinic/apyrimidinic endonuclease-1
-
 Homo sapiens

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
23
-
 electrophoretic mobility shift assay Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
 electrophoretic mobility shift assay Homo sapiens