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Literature summary for 4.2.99.18 extracted from

  • Zaky, A.; Busso, C.; Izumi, T.; Chattopadhyay, R.; Bassiouny, A.; Mitra, S.; Bhakat, K.K.
    Regulation of the human AP-endonuclease (APE1/Ref-1) expression by the tumor suppressor p53 in response to DNA damage (2008), Nucleic Acids Res., 36, 1555-1566.
    View publication on PubMedView publication on EuropePMC

Application

Application Comment Organism
medicine downregulation of APE1 is found to sensitize tumor cells to chemotherapy with induction of apoptosis Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
P53 after camptothecin treatment, p53 is a negative regulator of APE1 expression, APE1 promoter activity is repressed by wild-type p53, but not by mutant p53 Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
HCT-116 cell
-
Homo sapiens
-

Synonyms

Synonyms Comment Organism
AP-endonuclease
-
Homo sapiens
APE1
-
Homo sapiens
APE1/Ref-1
-
Homo sapiens