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Literature summary for 4.2.99.18 extracted from
- Virion-associated uracil DNA glycosylase-2 and apurinic/apyrimidinic endonuclease are involved in the degradation of APOBEC3G-edited nascent HIV-1 DNA (2007), J. Biol. Chem., 282, 11667-11675.
Application
| Application | Comment | Organism |
|---|---|---|
| medicine | after catalytically enzymatic activity or expression of APE is decreased, antiviral activity of APOBEC3G is partially inhibited in virus-producing cells | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| into the pSLV vector to generate pSLX-APE-Myc | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| additional information | the enzyme activity of apurinic/apyrimidinic endonuclease is blocked by APE-specific siRNAs | Homo sapiens |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| culture condition:CD4+ cell | - |
Homo sapiens | - |
| HEK-293T cell | - |
Homo sapiens | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Ape | - |
Homo sapiens |
| apurinic/apyrimidinic endonuclease | - |
Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
virion associated APE catalytic activity assay | Homo sapiens |
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