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Literature summary for 4.2.99.18 extracted from

  • Unk, I.; Haracska, L.; Johnson, R.E.; Prakash, S.; Prakash, L.
    Apurinic endonuclease activity of yeast Apn2 protein (2000), J. Biol. Chem., 275, 22427-22434.
    View publication on PubMed
Search for more literature for 4.2.99.18

Cloned(Commentary)

Cloned (Comment) Organism
Apn2 Saccharomyces cerevisiae

Protein Variants

Protein Variants Comment Organism
additional information deletion mutant delta369 and delta491, the C-terminal deletion does not affect the AP endonuclease activity, but the protein is defective in the removal of AP sites in vivo Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
NaCl inhibition above 150 mM Saccharomyces cerevisiae

Metals/Ions

Metals/Ions Comment Organism Structure
NaCl 150 mM, higher concentrations inhibit Saccharomyces cerevisiae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA Saccharomyces cerevisiae
-
 fragments of DNA
-
 ?

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
Apn2 Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA
-
 Saccharomyces cerevisiae fragments of DNA
-
 ?
DNA catalyzes the hydrolysis of the 5'-phosphodiester bond at the abasic site Saccharomyces cerevisiae fragments of DNA
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5 8.8
-
 Saccharomyces cerevisiae