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Literature summary for 4.2.99.18 extracted from

  • Grafstrom, R.H.; Park, L.; Grossman, L.
    Enzymatic repair of pyrimidine dimer-containing DNA. A 5' dimer DNA glycosylase: 3'-apyrimidinic endonuclease mechanism from Micrococcus luteus (1982), J. Biol. Chem., 257, 13465-13474.
    View publication on PubMed
Search for more literature for 4.2.99.18

Inhibitors

Inhibitors Comment Organism Structure
4-chloromercuribenzoate complete inhibition at 1 mM Bacillus subtilis
EDTA 96% inhibition at 20 mM Bacillus subtilis
NaCl complete inhibition at 1 M, 40% inhibition at 0.5 M Bacillus subtilis

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
26000
-
 4 * 26000, SDS-PAGE Bacillus subtilis
105000
-
 glycerol gradient centrifugation Bacillus subtilis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA Bacillus subtilis
-
 fragments of DNA
-
 ?

Organism

Organism UniProt Comment Textmining
Bacillus subtilis
-
-
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
 Bacillus subtilis

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA
-
 Bacillus subtilis fragments of DNA
-
 ?
DNA hydrolyzes phosphodiester bond near heat-induced apruinic sites in double or single strand DNA Bacillus subtilis fragments of DNA
-
 ?
additional information no substrate: alkylated sites Bacillus subtilis ?
-
 ?
additional information no substrate: native DNA Bacillus subtilis ?
-
 ?

Subunits

Subunits Comment Organism
tetramer 4 * 26000, SDS-PAGE Bacillus subtilis