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Literature summary for 4.2.3.9 extracted from
- Intermediacy of eudesmane cation during catalysis by aristolochene synthase (2010), J. Org. Chem., 75, 1119-1125.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Penicillium roqueforti |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 12,13-difluoro-farnesyl diphosphate | - |
Penicillium roqueforti |  |
| 4-aza-eudesm-11-ene | transition state analogue, competitive | Penicillium roqueforti | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00053 | - |
(2E,6E)-farnesyl diphosphate | - |
Penicillium roqueforti | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Mg2+ | - |
Penicillium roqueforti | |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 39000 | - |
39000, calculated | Penicillium roqueforti |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Penicillium roqueforti | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Penicillium roqueforti |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (2E,6E)-farnesyl diphosphate | - |
Penicillium roqueforti | (+)-aristolochene + diphosphate | major product (92%) | ? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 39000, calculated | Penicillium roqueforti |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| aristolochene synthase | - |
Penicillium roqueforti |
Turnover Number [1/s]
| Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.084 | - |
(2E,6E)-farnesyl diphosphate | - |
Penicillium roqueforti | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00024 | - |
4-aza-eudesm-11-ene, ammonium salt | in the presence of 0.25 mM diphosphate | Penicillium roqueforti | |
| 0.00035 | - |
4-aza-eudesm-11-ene, ammonium salt | - |
Penicillium roqueforti | |
kcat/KM [mM/s]
| kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 118 | - |
(2E,6E)-farnesyl diphosphate | - |
Penicillium roqueforti | |
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Release 2023.1 (January 2023)
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