Literature summary for 4.2.3.9 extracted from

Miller, D.J.; Yu, F.; Young, N.J.; Allemann, R.K.
Competitive inhibition of aristolochene synthase by phenyl-substituted farnesyl diphosphates: evidence of active site plasticity (2007), Org. Biomol. Chem., 5, 3287-3298.

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Inhibitors

Inhibitors	Comment	Organism	Structure
3-phenylfarnesyl diphosphate	-	Penicillium roqueforti
E-11-phenylfarnesyl diphosphate	-	Penicillium roqueforti
Z-11-phenylfarnesyl diphosphate	-	Penicillium roqueforti

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Mg2+	-	Penicillium roqueforti

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2-trans,6-trans-farnesyl diphosphate	Penicillium roqueforti	-	aristolochene + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Penicillium roqueforti	Q03471	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-trans,6-trans-farnesyl diphosphate	-	Penicillium roqueforti	aristolochene + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
aristolochene synthase	-	Penicillium roqueforti

Temperature Optimum [°C]

Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
25	-	activity assay	Penicillium roqueforti

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7.5	-	activity assay	Penicillium roqueforti

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0008	-	E-11-phenylfarnesyl diphosphate	-	Penicillium roqueforti
0.0012	-	Z-11-phenylfarnesyl diphosphate	-	Penicillium roqueforti
0.0012	-	3-phenylfarnesyl diphosphate	-	Penicillium roqueforti

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Release 2023.1 (January 2023)