Literature summary for 4.2.3.7 extracted from

Zu, L.; Xu, M.; Lodewyk, M.W.; Cane, D.E.; Peters, R.J.; Tantillo, D.J.
Effect of isotopically sensitive branching on product distribution for pentalenene synthase: support for a mechanism predicted by quantum chemistry (2012), J. Am. Chem. Soc., 134, 11369-11371.

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Protein Variants

Protein Variants	Comment	Organism
H309A	active site mutant	Streptomyces exfoliatus

Organism

Organism	UniProt	Comment	Textmining
Streptomyces exfoliatus	Q55012	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
farnesyl diphosphate	-	Streptomyces exfoliatus	pentalenene + diphosphate	mutant H309A produces 81% pentalenene and 13.4% Delta6-protoilludene, accompanied by minor quantities of germacrene A	?
additional information	isotopically sensitive branching experiments support a mechanism for pentalenene formation involving a 7-protoilludyl cation intermediate	Streptomyces exfoliatus	?	-	?

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Release 2023.1 (January 2023)