Literature summary for 4.2.3.7 extracted from

Seemann, M.; Zhai, G.; de Kraker, J.W.; Paschall, C.M.; Christianson, D.W.; Cane, D.E.
Pentalenene synthase. Analysis of active site residues by site-directed mutagenesis (2002), J. Am. Chem. Soc., 124, 7681-7689.

Search for more literature for 4.2.3.7

Protein Variants

Protein Variants	Comment	Organism
F77Y	compared to wild type, kcat/Km value is 20fold lower	Streptomyces exfoliatus
H309F	reaction products are pentalene plus varying proportions of (+)-germacrene A and protoilludene	Streptomyces exfoliatus
N219A	catalytically inactive	Streptomyces exfoliatus
N219D	compared to wild type, kcat/Km value is 3300fold lower, reaction products are pentalene plus beta-caryophyllene	Streptomyces exfoliatus
N219L	catalytically inactive	Streptomyces exfoliatus
W308F	reaction products are pentalene plus varying proportions of (+)-germacrene A	Streptomyces exfoliatus
W308F/H309F	reaction products are pentalene plus varying proportions of (+)-germacrene A	Streptomyces exfoliatus

Organism

Organism	UniProt	Comment	Textmining
Streptomyces exfoliatus	Q55012	-	-

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)