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Literature summary for 4.2.3.64 extracted from

  • Cane, D.; Tandon, M.; Prabhakaran, P.
    Epicubenol synthase and the enzymatic cyclization of farnesyl diphosphate (1993), J. Am. Chem. Soc., 115, 8103-8106.
No PubMed abstract available
Search for more literature for 4.2.3.64

Organism

Organism UniProt Comment Textmining
Streptomyces sp.
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Streptomyces sp. LL-B7
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2E,6E)-farnesyl diphosphate + H2O
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 Streptomyces sp. (+)-epicubenol + diphosphate reaction proceeds via 1,3-hydride shift. (3R)-nerolidyl diphosphate is an intermediate in the cyclization. Cyclization of [ 13,13,13-2H3]farnesy1 diphosphate with crude epicubenol synthase gives [ 13,13,13-2H3]epicubenol ?
(2E,6E)-farnesyl diphosphate + H2O
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 Streptomyces sp. LL-B7 (+)-epicubenol + diphosphate reaction proceeds via 1,3-hydride shift. (3R)-nerolidyl diphosphate is an intermediate in the cyclization. Cyclization of [ 13,13,13-2H3]farnesy1 diphosphate with crude epicubenol synthase gives [ 13,13,13-2H3]epicubenol ?