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Literature summary for 4.2.3.5 extracted from
- Chorismate synthase: an attractive target for drug development against orphan diseases (2007), Curr. Drug Targets, 8, 437-444.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
- |
Neurospora crassa |
Protein Variants
| Protein Variants | Comment | Organism |
|---|---|---|
| H106A | activity 10fold decreased | Neurospora crassa |
| H17A | activity 20fold decreased | Neurospora crassa |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (6S)-6-fluoro-5-enolpyruvylshikimate 3-phosphate | competitive inhibitor | Neurospora crassa |  |
| O2 | activity only in anaerobic conditions | Streptococcus pneumoniae | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 5-enolpyruvylshikimate 3-phosphate | Neurospora crassa | - |
chorismate + phosphate | - |
? | |
| 5-enolpyruvylshikimate 3-phosphate | Salmonella enterica | - |
chorismate + phosphate | - |
? | |
| 5-enolpyruvylshikimate 3-phosphate | Yersinia enterocolitica | - |
chorismate + phosphate | - |
? | |
| 5-enolpyruvylshikimate 3-phosphate | Brucella suis | - |
chorismate + phosphate | - |
? | |
| 5-enolpyruvylshikimate-3-phosphate | Streptococcus pneumoniae | - |
chorismate + phosphate | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Brucella suis | - |
- |
- |
| Neurospora crassa | - |
- |
- |
| Salmonella enterica | - |
- |
- |
| Streptococcus pneumoniae | - |
- |
- |
| Yersinia enterocolitica | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| (6S)-6-fluoro-5-enolpyruvylshikimate 3-phosphate | converion rate between 270 and 370 times slower than natural substrate conversion | Streptococcus pneumoniae | 6-fluorochorismate + phosphate | - |
? | |
| 5-enolpyruvylshikimate 3-phosphate | - |
Neurospora crassa | chorismate + phosphate | - |
? | |
| 5-enolpyruvylshikimate 3-phosphate | - |
Salmonella enterica | chorismate + phosphate | - |
? | |
| 5-enolpyruvylshikimate 3-phosphate | - |
Yersinia enterocolitica | chorismate + phosphate | - |
? | |
| 5-enolpyruvylshikimate 3-phosphate | - |
Brucella suis | chorismate + phosphate | - |
? | |
| 5-enolpyruvylshikimate-3-phosphate | - |
Streptococcus pneumoniae | chorismate + phosphate | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| chorismate synthase | - |
Neurospora crassa |
| chorismate synthase | - |
Streptococcus pneumoniae |
| chorismate synthase | - |
Salmonella enterica |
| chorismate synthase | - |
Yersinia enterocolitica |
| chorismate synthase | - |
Brucella suis |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| FMN | - |
Neurospora crassa | |
| FMN | - |
Streptococcus pneumoniae | |
| FMN | - |
Salmonella enterica | |
| FMN | - |
Yersinia enterocolitica | |
| FMN | - |
Brucella suis | |
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