Literature summary for 4.2.3.4 extracted from

Rapp, J.; Wagner, B.; Brilisauer, K.; Forchhammer, K.
In vivo inhibition of the 3-dehydroquinate synthase by 7-deoxysedoheptulose depends on promiscuous uptake by sugar transporters in cyanobacteria (2021), Front. Microbiol., 12, 692986 .

Search for more literature for 4.2.3.4

Cloned(Commentary)

Cloned (Comment)	Organism
expression in Escherichia coli	Trichormus variabilis

Inhibitors

Inhibitors	Comment	Organism	Structure
7-deoxysedoheptulose	competitive, inhibitor can be taken up by the fructose ABC-transporter	Trichormus variabilis

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0018	-	7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate	pH 7.5, 29°C	Trichormus variabilis

Organism

Organism	UniProt	Comment	Textmining
Trichormus variabilis	Q3M4V2	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate	-	Trichormus variabilis	3-dehydroquinate + phosphate	-	?

Subunits

Subunits	Comment	Organism
?	x * 39000, SDS-PAGE	Trichormus variabilis

Synonyms

Synonyms	Comment	Organism
aroB	-	Trichormus variabilis
DHQS	-	Trichormus variabilis

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.0176	-	7-deoxysedoheptulose	pH 7.5, 29°C	Trichormus variabilis

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.0213	-	pH 7.5, 29°C	Trichormus variabilis	7-deoxysedoheptulose

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Release 2023.1 (January 2023)