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Literature summary for 4.2.3.4 extracted from

  • Mehdi, S.; Frost, J.W.; Knowles, J.R.
    Dehydroquinate synthase from Escherichia coli, and its substrate 3-deoxy-D-arabino-heptulosonic acid 7-phosphate (1987), Methods Enzymol., 142, 306-314.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
overexpression in Escherichia coli Escherichia coli

Inhibitors

Inhibitors Comment Organism Structure
EGTA
-
 Escherichia coli

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.033 0.055 3-deoxy-D-arabino-heptulosonic acid 7-phosphate
-
 Escherichia coli

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
38880
-
 HPLC Escherichia coli
38880
-
 denaturing gel electrophoresis Escherichia coli
44000
-
 HPLC Escherichia coli

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3-deoxy-D-arabino-heptulosonic acid 7-phosphate Escherichia coli
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Escherichia coli

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
44
-
-
 Escherichia coli

Storage Stability

Storage Stability Organism
-70°C, more than 1 year Escherichia coli

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3-deoxy-D-arabino-heptulosonic acid 7-phosphate
-
 Escherichia coli 3-dehydroquinate + phosphate
-
 ir
3-deoxy-D-arabino-heptulosonic acid 7-phosphate
-
 Escherichia coli ?
-
 ?

Cofactor

Cofactor Comment Organism Structure
NAD+ 1 mol of NAD+ per mol of protein Escherichia coli