Literature summary for 4.2.3.24 extracted from

Lindahl, A.L.; Olsson, M.E.; Mercke, P.; Tollbom, O.; Schelin, J.; Brodelius, M.; Brodelius, P.E.
Production of the artemisinin precursor amorpha-4,11-diene by engineered Saccharomyces cerevisiae (2006), Biotechnol. Lett., 28, 571-580.

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Application

Application	Comment	Organism
medicine	amorpha-4,11-diene is a presursor of artemisinin, artemisinin and derivates are used for the treatment of malaria	Artemisia annua

Cloned(Commentary)

Cloned (Comment)	Organism
into the pYeDP60 vector for expression in Saccharomyces cerevisiae, and, in addition, introduced into the yeast genome by homologous recombination	Artemisia annua

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
2-trans,6-trans-farnesyl diphosphate	Artemisia annua	-	amorpha-4,11-diene + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Artemisia annua	Q9AR04	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
2-trans,6-trans-farnesyl diphosphate	-	Artemisia annua	amorpha-4,11-diene + diphosphate	-	?

Synonyms

Synonyms	Comment	Organism
ADS	-	Artemisia annua
amorpha-4,11-diene synthase	-	Artemisia annua

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Release 2023.1 (January 2023)