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Literature summary for 4.2.3.24 extracted from

  • Wallaart, T.E.; Bouwmeester, H.J.; Hille, J.; Poppinga, L.; Maijers, N.C.A.
    Amorpha-4,11-diene synthase: cloning and functional expression of a key enzyme in the biosynthetic pathway of the novel antimalarial drug artemisinin (2001), Planta, 212, 460-465.
    View publication on PubMed
Search for more literature for 4.2.3.24

Application

Application Comment Organism
synthesis production of amorpha-4,11-diene, expression in Nicotiana tabacum gives 0.2 to 1.7 ng per g fresh weight Artemisia annua

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
63900
-
 x * 63900, calculated Artemisia annua

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Artemisia annua key enzyme in the biosynthetic pathway of the antimalarial drug artemisinin ?
-
 ?

Organism

Organism UniProt Comment Textmining
Artemisia annua Q9AR04 expression in Escherichia coli and nicotiana tabacum
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
farnesyl diphosphate
-
 Artemisia annua amorpha-4,7-diene + diphosphate major product, minor product is beat-sesquiphellandrene ?
additional information key enzyme in the biosynthetic pathway of the antimalarial drug artemisinin Artemisia annua ?
-
 ?

Subunits

Subunits Comment Organism
? x * 63900, calculated Artemisia annua

pI Value

Organism Comment pI Value Maximum pI Value
Artemisia annua calculated
-
 5.66