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Literature summary for 4.2.3.22 extracted from

  • Gust, B.; Challis, G.L.; Fowler, K.; Kieser, T.; Chater, K.F.
    PCR-targeted Streptomyces gene replacement identifies a protein domain needed for biosynthesis of the sesquiterpene soil odor geosmin (2003), Proc. Natl. Acad. Sci. USA, 100, 1541-1546.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.2.3.22

Cloned(Commentary)

Cloned (Comment) Organism
construction of an ordered library of Supercos-1 clones, DNA sequence determination and analysis, subcloning in Escherichia coli Streptomyces coelicolor

Protein Variants

Protein Variants Comment Organism
additional information construction of a cyc2 disruption mutant inactive in geosmin biosynthesis Streptomyces coelicolor

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(2E,6E)-farnesyl diphosphate + H2O Streptomyces coelicolor enzyme is essential for geosmin biosynthesis (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate
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Organism

Organism UniProt Comment Textmining
Streptomyces coelicolor
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 several strains, gene cyc2 or Sco6073 encoding an enzyme with two sesquiterpene synthase domains
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2E,6E)-farnesyl diphosphate + H2O enzyme is essential for geosmin biosynthesis Streptomyces coelicolor (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate
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 ?
(2E,6E)-farnesyl diphosphate + H2O reaction is catalyzed by one of two sesquiterpene domains of the enzyme Streptomyces coelicolor (1E,4S,5E,7R)-germacra-1(10),5-dien-11-ol + diphosphate
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 ?

Synonyms

Synonyms Comment Organism
sesquiterpene synthase
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 Streptomyces coelicolor