Literature summary for 4.2.3.20 extracted from

Lucker, J.; El Tamer, M.K.; Schwab, W.; Verstappen, F.W.; van der Plas, L.H.; Bouwmeester, H.J.; Verhoeven, H.A.
Monoterpene biosynthesis in lemon (Citrus limon). cDNA isolation and functional analysis of four monoterpene synthases (2000), Eur. J. Biochem., 269, 3160-3171.

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Activating Compound

Activating Compound	Comment	Organism	Structure
Mn2+	inhibition above 0.6 mM, activation below	Citrus limon

Cloned(Commentary)

Cloned (Comment)	Organism
-	Citrus limon

Inhibitors

Inhibitors	Comment	Organism	Structure
geranyl diphosphate	substrate inhibition above 0.01 mM; substrate inhibition above 0.01 mM	Citrus limon
K+	maximum inhibition above 100 mM; maximum inhibition above 100 mM	Citrus limon
Mn2+	above 0.6 mM, activation below; above 0.6 mM, activation below	Citrus limon

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0007	-	geranyl diphosphate	-	Citrus limon

Metals/Ions

Metals/Ions	Comment	Organism	Structure
additional information	divalent metal ion required, probably Mn2+	Citrus limon

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
geranyl diphosphate	Citrus limon	-	(+)-(R)-limonene + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Citrus limon	Q8L5K1	-	-
Citrus limon	Q8L5K3	-	-

Reaction

Reaction	Comment	Organism	Reaction ID
geranyl diphosphate = (R)-limonene + diphosphate	requires a divalent metal ion (preferably Mn2+) for catalysis	Citrus limon	a

Source Tissue

Source Tissue	Comment	Organism	Textmining
fruit	peel of young developing fruit	Citrus limon	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
geranyl diphosphate	-	Citrus limon	(+)-(R)-limonene + diphosphate	-	?
geranyl diphosphate	-	Citrus limon	(+)-(R)-limonene + diphosphate	product is exclusively R-(+)-limonene	?

pH Optimum

pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
7	-	-	Citrus limon

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Release 2023.1 (January 2023)