Literature summary for 4.2.3.18 extracted from

Peters, R.J.; Carter, O.A.; Zhang, Y.; Matthews, B.W.; Croteau, R.B.
Bifunctional abietadiene synthase: mutual structural dependence of the active sites for protonation-initiated and ionization-initiated cyclizations (2003), Biochemistry, 42, 2700-2707.

Search for more literature for 4.2.3.18

Protein Variants

Protein Variants	Comment	Organism
DELTA:107-868	lower turnover with copalyl diphosphate than wild-type	Abies grandis
DELTA:85-849	no turnover with copalyl diphosphate	Abies grandis
rAS:D96A	nearly the same turnover with copalyl diphosphate like wild-type	Abies grandis
rAS:K86A/R87A	lower turnover with copalyl diphosphate than wild-type	Abies grandis

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.0005	-	copalyl diphosphate	mutants rAS:K86A/R87A	Abies grandis
0.0007	-	copalyl diphosphate	mutants ASDELTA:107-868	Abies grandis
0.0009	-	copalyl diphosphate	mutant rAS:D96A	Abies grandis

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
(+)-copalyl-diphosphate	Abies grandis	-	(-)-abietadiene + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Abies grandis	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(+)-copalyl-diphosphate	-	Abies grandis	(-)-abietadiene + diphosphate	-	?

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Release 2023.1 (January 2023)