Literature summary for 4.2.3.17 extracted from

Lin, X.; Hezari, M.; Koepp, A.E.; Floss, H.G.; Croteau, R.
Mechanism of taxadiene synthase, a diterpene cyclase that catalyzes the first step of taxol biosynthesis in pacific yew (1996), Biochemistry, 35, 2968-2977.

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Application

Application	Comment	Organism
medicine	chemotherapeutic agent against a range of cancers, including ovarian and breast cancer	Taxus brevifolia

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
geranylgeranyl diphosphate	Taxus brevifolia	catalyzes the first step in taxol biosynthesis	taxa-4,11-diene + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Taxus brevifolia	-	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Taxus brevifolia

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
geranylgeranyl diphosphate	-	Taxus brevifolia	taxa-4(5),11(12)-diene + diphosphate	-	?
geranylgeranyl diphosphate	catalyzes the first step in taxol biosynthesis	Taxus brevifolia	taxa-4,11-diene + diphosphate	-	?

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Release 2023.1 (January 2023)