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Literature summary for 4.2.3.156 extracted from

  • Pan, J.J.; Solbiati, J.O.; Ramamoorthy, G.; Hillerich, B.S.; Seidel, R.D.; Cronan, J.E.; Almo, S.C.; Poulter, C.D.
    Biosynthesis of squalene from farnesyl diphosphate in bacteria: three steps catalyzed by three enzymes (2015), ACS Cent. Sci., 1, 77-82.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.2.3.156

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Zymomonas mobilis
expression in Escherichia coli Rhodopseudomonas palustris

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
presqualene diphosphate + H2O Zymomonas mobilis
-
 hydroxysqualene + diphosphate
-
 ?
presqualene diphosphate + H2O Rhodopseudomonas palustris
-
 hydroxysqualene + diphosphate
-
 ?
presqualene diphosphate + H2O Rhodopseudomonas palustris ATCC BAA-98
-
 hydroxysqualene + diphosphate
-
 ?
presqualene diphosphate + H2O Zymomonas mobilis ZM4
-
 hydroxysqualene + diphosphate
-
 ?

Organism

Organism UniProt Comment Textmining
Rhodopseudomonas palustris Q6N3F1
-
-
Rhodopseudomonas palustris ATCC BAA-98 Q6N3F1
-
-
Zymomonas mobilis Q5NP67
-
-
Zymomonas mobilis ZM4 Q5NP67
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information no substrate: farnesyl diphosphate Zymomonas mobilis ?
-
 ?
additional information no substrate: farnesyl diphosphate Rhodopseudomonas palustris ?
-
 ?
additional information no substrate: farnesyl diphosphate Rhodopseudomonas palustris ATCC BAA-98 ?
-
 ?
additional information no substrate: farnesyl diphosphate Zymomonas mobilis ZM4 ?
-
 ?
presqualene diphosphate + H2O
-
 Zymomonas mobilis hydroxysqualene + diphosphate
-
 ?
presqualene diphosphate + H2O
-
 Rhodopseudomonas palustris hydroxysqualene + diphosphate
-
 ?
presqualene diphosphate + H2O
-
 Rhodopseudomonas palustris ATCC BAA-98 hydroxysqualene + diphosphate
-
 ?
presqualene diphosphate + H2O
-
 Zymomonas mobilis ZM4 hydroxysqualene + diphosphate
-
 ?

Synonyms

Synonyms Comment Organism
hpnC
-
 Zymomonas mobilis
hpnC
-
 Rhodopseudomonas palustris
RPA3743
-
 Rhodopseudomonas palustris
ZMO0869
-
 Zymomonas mobilis

General Information

General Information Comment Organism
physiological function the gene products of HpnC, HpnD, HpnE, and HpnF are responsible for conversion of farnesyl diphosphate to hopene or related pentacyclic metabolites. HpnD catalyzes formation of presqualene diphosphate from two molecules of farnesyl diphosphate. HpnC converts presqualene diphosphate to hydroxysqualene, and HpnE, a member of the amine oxidoreductase family, reduces hydroxysqualene to squalene Rhodopseudomonas palustris