Cloned (Comment) | Organism |
---|---|
gene cop4, phylogenetic analysis | Coprinopsis cinerea |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Coprinopsis cinerea | Cop4 synthesizes delta-cadinene as its major product, cf. EC 4.2.3.13. Cop4 cultures produce several sesquiterpene compounds betacubebene, sativene, beta-copaene, and cubebol | ? | - |
? | |
additional information | Coprinopsis cinerea ATCC MYA-4618 | Cop4 synthesizes delta-cadinene as its major product, cf. EC 4.2.3.13. Cop4 cultures produce several sesquiterpene compounds betacubebene, sativene, beta-copaene, and cubebol | ? | - |
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Organism | UniProt | Comment | Textmining |
---|---|---|---|
Coprinopsis cinerea | A8NU13 | gene cop4 | - |
Reaction | Comment | Organism | Reaction ID |
---|---|---|---|
(2E,6E)-farnesyl diphosphate = beta-copaene + diphosphate | the reaction mechanism requires first the isomerization of all-trans (E,E)-FPP at the 2,3 double bond to generate a cisoid-farnesyl cation. Cop4 then catalyzes a 1,10 ring closure of this farnesyl cation isomer to form the secondary cis-germacrene-dienyl cation. Cop4 generates a tertiary cadinyl cation which upon deprotonation yields its major cyclization product delta-cadinene. The cadinyl cation reacts further to yield other cyclization products beta-cubebene, cubebol, beta-copaene, and sativene | Coprinopsis cinerea |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Cop4 synthesizes delta-cadinene as its major product, cf. EC 4.2.3.13. Cop4 cultures produce several sesquiterpene compounds betacubebene, sativene, beta-copaene, and cubebol | Coprinopsis cinerea | ? | - |
? | |
additional information | Escherichia coli strains expressing Cop4 accumulate delta-cadinene as the major terpenoid, accounting for about 40% of the total sesquiterpenes detected | Coprinopsis cinerea | ? | - |
? | |
additional information | Cop4 synthesizes delta-cadinene as its major product, cf. EC 4.2.3.13. Cop4 cultures produce several sesquiterpene compounds betacubebene, sativene, beta-copaene, and cubebol | Coprinopsis cinerea ATCC MYA-4618 | ? | - |
? | |
additional information | Escherichia coli strains expressing Cop4 accumulate delta-cadinene as the major terpenoid, accounting for about 40% of the total sesquiterpenes detected | Coprinopsis cinerea ATCC MYA-4618 | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Cop4 | - |
Coprinopsis cinerea |
sesquiterpene synthase | - |
Coprinopsis cinerea |
General Information | Comment | Organism |
---|---|---|
additional information | Cop4 is a delta-cadinene synthase | Coprinopsis cinerea |