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Literature summary for 4.2.3.127 extracted from

  • Agger, S.; Lopez-Gallego, F.; Schmidt-Dannert, C.
    Diversity of sesquiterpene synthases in the basidiomycete Coprinus cinereus (2009), Mol. Microbiol., 72, 1181-1195.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

Cloned (Comment) Organism
gene cop4, phylogenetic analysis Coprinopsis cinerea

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Coprinopsis cinerea Cop4 synthesizes delta-cadinene as its major product, cf. EC 4.2.3.13. Cop4 cultures produce several sesquiterpene compounds betacubebene, sativene, beta-copaene, and cubebol ?
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additional information Coprinopsis cinerea ATCC MYA-4618 Cop4 synthesizes delta-cadinene as its major product, cf. EC 4.2.3.13. Cop4 cultures produce several sesquiterpene compounds betacubebene, sativene, beta-copaene, and cubebol ?
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Organism

Organism UniProt Comment Textmining
Coprinopsis cinerea A8NU13 gene cop4
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Reaction

Reaction Comment Organism Reaction ID
(2E,6E)-farnesyl diphosphate = beta-copaene + diphosphate the reaction mechanism requires first the isomerization of all-trans (E,E)-FPP at the 2,3 double bond to generate a cisoid-farnesyl cation. Cop4 then catalyzes a 1,10 ring closure of this farnesyl cation isomer to form the secondary cis-germacrene-dienyl cation. Cop4 generates a tertiary cadinyl cation which upon deprotonation yields its major cyclization product delta-cadinene. The cadinyl cation reacts further to yield other cyclization products beta-cubebene, cubebol, beta-copaene, and sativene Coprinopsis cinerea

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
additional information Cop4 synthesizes delta-cadinene as its major product, cf. EC 4.2.3.13. Cop4 cultures produce several sesquiterpene compounds betacubebene, sativene, beta-copaene, and cubebol Coprinopsis cinerea ?
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additional information Escherichia coli strains expressing Cop4 accumulate delta-cadinene as the major terpenoid, accounting for about 40% of the total sesquiterpenes detected Coprinopsis cinerea ?
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additional information Cop4 synthesizes delta-cadinene as its major product, cf. EC 4.2.3.13. Cop4 cultures produce several sesquiterpene compounds betacubebene, sativene, beta-copaene, and cubebol Coprinopsis cinerea ATCC MYA-4618 ?
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additional information Escherichia coli strains expressing Cop4 accumulate delta-cadinene as the major terpenoid, accounting for about 40% of the total sesquiterpenes detected Coprinopsis cinerea ATCC MYA-4618 ?
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?

Synonyms

Synonyms Comment Organism
Cop4
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Coprinopsis cinerea
sesquiterpene synthase
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Coprinopsis cinerea

General Information

General Information Comment Organism
additional information Cop4 is a delta-cadinene synthase Coprinopsis cinerea