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Literature summary for 4.2.3.122 extracted from

  • McGeady, P.; Croteau, R.
    Isolation and characterization of an active-site peptide from a monoterpene cyclase labeled with a mechanism-based inhibitor (1995), Arch. Biochem. Biophys., 317, 149-155.
    View publication on PubMed

Inhibitors

Inhibitors Comment Organism Structure
(+)-(1R)-N,N,4-trimethyl-3-cyclohexenamine aza-analogue of terpenyl cation, uncompetitive Salvia officinalis
(+)-dimethyl-[(1R)-4-methylcyclohex-3-en-1-yl]sulfonium iodide thia-analogue of terpenyl cation, uncompetitive Salvia officinalis
(-)-(1S)-N,N,4-trimethyl-3-cyclohexenamine aza-analogue of terpenyl cation, uncompetitive Salvia officinalis
(-)-dimethyl-[(1S)-4-methylcyclohex-3-en-1-yl]sulfonium iodide thia-analogue of terpenyl cation, uncompetitive Salvia officinalis

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0016
-
geranyl diphosphate pH 6.8, 31°C Salvia officinalis
0.009
-
(RS)-alpha-terpinyl diphosphate pH 6.8, 31°C Salvia officinalis

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ preferred divalent cation, Km value about 3 mM Salvia officinalis

Organism

Organism UniProt Comment Textmining
Salvia officinalis
-
-
-

Purification (Commentary)

Purification (Comment) Organism
partial Salvia officinalis

Source Tissue

Source Tissue Comment Organism Textmining
leaf
-
Salvia officinalis
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(RS)-alpha-terpinyl diphosphate
-
Salvia officinalis limonene + diphosphate about 90% limonene, 10% terpinolene. Enzyme is unable to discriminate between enantiomers of alpha-terpinyl diphosphate ?
geranyl diphosphate
-
Salvia officinalis (+)-alpha-pinene + diphosphate reaction proceeds via (3R)-linalyl diphosphate and the (4R)-alpha-terpinyl cation. Products are (+)-alpha-pinene, and lesser amounts of related olefins ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.0007
-
(-)-(1S)-N,N,4-trimethyl-3-cyclohexenamine pH 6.8, 31°C, presence of diphosphate Salvia officinalis
0.001
-
(+)-(1R)-N,N,4-trimethyl-3-cyclohexenamine pH 6.8, 31°C, presence of diphosphate Salvia officinalis
0.0011
-
(-)-(1S)-N,N,4-trimethyl-3-cyclohexenamine pH 6.8, 31°C Salvia officinalis
0.002
-
(+)-(1R)-N,N,4-trimethyl-3-cyclohexenamine pH 6.8, 31°C Salvia officinalis
0.004
-
(-)-dimethyl-[(1S)-4-methylcyclohex-3-en-1-yl]sulfonium iodide pH 6.8, 31°C, presence of diphosphate Salvia officinalis
0.0058
-
(+)-dimethyl-[(1R)-4-methylcyclohex-3-en-1-yl]sulfonium iodide pH 6.8, 31°C, presence of diphosphate Salvia officinalis
0.0071
-
(-)-dimethyl-[(1S)-4-methylcyclohex-3-en-1-yl]sulfonium iodide pH 6.8, 31°C Salvia officinalis
0.0092
-
(+)-dimethyl-[(1R)-4-methylcyclohex-3-en-1-yl]sulfonium iodide pH 6.8, 31°C Salvia officinalis