Literature summary for 4.2.3.120 extracted from

Savage, T.J.; Ichii, H.; Hume, S.D.; Little, D.B.; Croteau, R.
Monoterpene synthases from gymnosperms and angiosperms: stereospecificity and inactivation by cysteinyl- and arginyl-directed modifying reagents (1995), Arch. Biochem. Biophys., 320, 257-265.

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Inhibitors

Inhibitors	Comment	Organism	Structure
additional information	enzyme is inactivated by thiol-modifying agents, coincubation with substrate and metal-ion cofactor does not protect	Pinus contorta
Phenylglyoxal	inactivation, coincubation with substrate and metal-ion cofactor reduces the rate of inactivation by 10-fold	Pinus contorta

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.001	-	(3S)-linalyl diphosphate	pH 7.0, 31°C	Pinus contorta
0.0025	-	geranyl diphosphate	pH 7.0, 31°C	Pinus contorta
0.0032	-	(3R)-linalyl diphosphate	pH 7.0, 31°C	Pinus contorta

Organism

Organism	UniProt	Comment	Textmining
Pinus contorta	-	isoform cyclase IV	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
(3R)-linalyl diphosphate	-	Pinus contorta	myrcene + diphosphate	-	?
(3S)-linalyl diphosphate	-	Pinus contorta	(-)-beta-pinene + diphosphate	63% (-)-beta-pinene, 25.8% (+-)carene, and 6.7% alpha-pinene in almost racemic mixture.Products are exactly the same as with geranyl diphosphate	?
geranyl diphosphate	-	Pinus contorta	(-)-beta-pinene + diphosphate	63% (-)-beta-pinene, 25.8% (+-)carene, and 6.7% alpha-pinene in almost racemic mixture. (+)-alpha-pinene arises from the rare isomerization of geranyl diphosphate to (3R)-linalyl diphosphate	?

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Release 2023.1 (January 2023)