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Literature summary for 4.2.2.7 extracted from
- Differential effects of heparitinase I and heparitinase III on endothelial tube formation in vitro (2010), Biochem. Biophys. Res. Commun., 398, 191-193.
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pedobacter heparinus | - |
- |
- |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| additional information | propagated in bovine lung microvascular endothelial cells | Pedobacter heparinus | - |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Hep III | - |
Pedobacter heparinus |
| heparin lyase | - |
Pedobacter heparinus |
| heparitinase III | - |
Pedobacter heparinus |
General Information
| General Information | Comment | Organism |
|---|---|---|
| physiological function | differential effects of heparitinase I, EC 4.2.2.8, and heparitinase III on endothelial tube formation. The enzymes inhibit tube formation and reduce tumor-derived neovascularization in vivo by reducing bFGF binding and subsequent signaling, HepIII has a stronger effect than Hep I. Heparitinases, isolated from Flavobacterium heparinum, cleave heparan sulfate chains at defined locations, Hep III cleaves near sulfated iduronic acid residues and at highly sulfated regions. Hep III therefore may disrupt the growth factor binding domains that are important for angiogenesis | Pedobacter heparinus |
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Release 2023.1 (January 2023)
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